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European Journal of Heart Failure 2007 9(6-7):558-567; doi:10.1016/j.ejheart.2007.02.003
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© 2007 European Society of Cardiology

Cellular cardiomyoplasty in large myocardial infarction: Can the beneficial effect be enhanced by ACE-inhibitor therapy?

Emerson L. Olivaresa,b,*, Ricardo H. Costa-e-Sousaa,b, João P.S. Werneck-de-Castroa,f, Vanessa Pinho-Ribeiroa, Márcia G. Silvac, Karla C. Ribeiroa, Elisabete C. Mattosc, Regina C.S. Goldenberga, Antonio C. Campos de Carvalhoa,d and Masako Oya Masudaa,e

a Instituto de Biofísica Carlos Chagas Filho UFRJ, Rio de Janeiro, CEP 21949-9000, Brazil
b Departamento de Ciências Fisiológicas, Instituto de Biologia, UFRRJ, Seropédica, CEP 23890-000, Brazil
c Ecodata Exames Médicos LTDA, Rio de Janeiro, CEP 22020-120, Brazil
d Albert Einstein College of Medicine, Bronx, New York 10461, USA
e Fundação CECIERJ, Rio de Janeiro, CEP 20943-001, Brazil
f Departamento de Biociências da Atividade Física, UFRJ, Rio de Janeiro, CEP 21949-9000, Brazil

* Corresponding author. Departamento de Ciências Fisiológicas, Instituto de Biologia, Universidade Federal Rural do Rio de Janeiro BR 465, Km 7, 23890-000, Seropédica, Rio de Janeiro, Brazil. Tel.: +55 21 26821210. E-mail address: elopes{at}ufrrj.br


  Abstract

Background: Cellular cardiomyoplasty with bone marrow derived stromal (MSC) and mononuclear (BMNC) cells has been shown to improve performance of infarcted hearts. We performed a comparative study with MSC and BMNC and tested the hypothesis that captopril treatment could enhance the beneficial effect of cell therapy in large myocardial infarctions.

Methods: Male syngeneic Wistar rats underwent experimental infarction and were randomized to receive 1–3x106 MSC, 108 BMNC or vehicle (BSS group). Two additional groups were treated with captopril and received 1–3x106 MSC (Cap.MSC) or vehicle (Cap).

Results: The ejection fraction (EF%) of MSC and BMNC-treated rats was higher than in the BSS rats, eight weeks after transplantation (33.0±4.0, 34.0±2.0 and 20.0±2.0% respectively, P<0.01). Both captopril-treated groups improved EF% similarly. But only captopril plus MSC treatment almost restored cardiac function to control levels, 8 weeks after injection (60.50±5.40% vs. 41.00±4.50% in Cap.MSC and Cap respectively, P<0.05). Many DAPI-labelled cells were found in the scar tissue of the left ventricle only in the Cap.MSC group.

Conclusions: Cell transplantation with both MSC and BMNC produced a similar stabilisation of heart function, but the success of the cell engraftment and the recovery of cardiac performance were dependent on concomitant treatment with captopril.

Key Words: Cell therapy • Stem cells • Myocardial infarction • Captopril

Received July 21, 2006; Revised October 6, 2006; Accepted February 6, 2007


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