© 2007 European Society of Cardiology
Impact of diabetes on left ventricular diastolic function in patients with arterial hypertension
a Department of Cardiology and Pneumology, University of Göttingen Robert-Koch-Str. 40, 37075 Göttingen, Germany
b Department of Psychosomatic Medicine and Psychotherapy, University of Marburg Germany
c Department of Clinical Chemistry, University of Göttingen Göttingen, Germany
d Institute for Mathematical Stochastics, University of Göttingen Göttingen, Germany
e Department of Genetic Epidemiology, University of Göttingen Göttingen, Germany
f Department of General Practice, University of Göttingen Göttingen, Germany
* Corresponding author. Tel.: +49 551 39 8925; fax: +49 551 39 19127.
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Abstract |
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Aims: To analyse the effect of diabetes (DM) on diastolic function in hypertensive patients.
Methods: 439 hypertensive patients were selected for participation in this study. All participants had an echocardiographic evaluation of systolic and diastolic function. The overall degree of diastolic function and specific parameters (e.g. E/Ea ratio) were analysed.
Results: We divided the cohort (63±10 years) into those with diabetes mellitus (DM(+), n=124) and without diabetes mellitus (DM(–), n=315). The prevalence of normal diastolic function was lower in DM(+) than DM(–) (19.4% vs. 30.8%); mild (65.3% vs. 60.0%) and moderate/ severe diastolic dysfunction were more frequent in DM(+) (15.3% vs. 9.2%, p=0.022). The E/Ea ratio, an estimate of left ventricular end-diastolic pressure, was significantly higher in DM(+) (12.3±4.4) as compared to DM(–) (10.8±3.6, p<0.001). Sex-specific analysis revealed that the effect of DM on diastolic function was mainly limited to the male subgroup. Multivariate logistic regression analysis showed that diabetes affected diastolic function in males independent of blood pressure, left ventricular mass index, concomitant medication and prevalence of coronary artery disease.
Conclusion: Diabetes negatively affects diastolic function in patients with arterial hypertension. This effect is mainly confined to the male subgroup.
Key Words: Diabetes • Diastolic function • Heart failure • Echocardiography
Received January 31, 2006; Revised October 5, 2006; Accepted January 2, 2007
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