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European Journal of Heart Failure 2007 9(2):120-123; doi:10.1016/j.ejheart.2006.12.009
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© 2007 European Society of Cardiology

Promising aspects and caveats of studies on anti-apoptotic therapies in patients with heart failure

Ali Khoynezhad

Section of Cardiothoracic Surgery, University of Nebraska Medical Center Omaha, NE, United States akhoynezhad@unmc.edu Tel.: +1 402 559 4424; fax: +1 402 559 6913.

Key Words: Heart failure • Apoptosis • Heart physiology • Cell signaling • Myocardial remodeling

Received November 3, 2006;
The first 10% of the full text of this article appears below.

The prevalence of heart failure is 1-2%, and it accounts for about 1-2% of total health-care budget in Europe [1]. Despite significant advances in medical and surgical treatment of heart failure this important challenge remains: During the last two decades, congestive heart failure has become an increasingly frequent reason for hospital admission and clearly represents a major health problem.

Within the past decade, there is accumulated evidence that apoptosis contributes significantly to the pathogenesis of heart failure. It is an important component of the remodeling process and the transition from adaptive myocardial condition to end-stage cardiac failure (Fig. 1). Apoptosis is executed by a family of ubiquitously expressed cysteine proteases termed caspases. Caspases are present in the cell as inactive pro-caspases . . . [Full Text of this Article]


   1. Significance of cardiac apoptosis in patients with heart failure
 

   2. Caveats in studies involving cardiocyte apoptosis
 

   3. Anti-apoptotic strategies in the treatment of patients with heart failure
 

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