© 2007 European Society of Cardiology
Is there a common genetic basis for all familial cardiomyopathies?
Charité-Universitätsmedizin Berlin/Cardiology Campus Buch & Virchow-Klinikum, and Max Delbrück Center for Molecular Medicine Berlin, Germany
* Corresponding author. Charité-Universitétsmedizin Berlin, Campus Buch, Haus 129, Wiltbergstrasse 50, 13125 Berlin, Germany. Tel.: +49 30 9417 2508; fax: +49 30 9417 2279. E-mail address: andreas.perrot@charite.de
Received December 27, 2005;
| The first 10% of the full text of this article appears below. |
The most exciting phrase to hear in science, the one that heralds new discoveries, is not "Eureka! (I found it!)" but rather "Hmm... that's funny..."Isaac Asimov, author and biochemist (1920-1992)
According to the 1995 World Health Organization definition, cardiomyopathies are "diseases of the myocardium associated with cardiac dysfunction" [1]. Traditionally, cardiomyopathies are differentiated according to the pathologic changes in cardiac morphology and function using cardiac imaging and invasive methods to exclude coronary artery disease. The two distinct patterns of cardiac remodelling, hypertrophy and dilation, are the main criteria for classifying a patient's disease as a hypertrophic or a dilated cardiomyopathy; cardiac filling is used to define restrictive cardiomyopathy. For the practicing physician, hypertrophic (HCM), dilated (DCM), and restrictive cardiomyopathy (RCM) are clearly distinct disorders.
The birth