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European Journal of Heart Failure 2006 8(7):736-743; doi:10.1016/j.ejheart.2006.01.012
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© 2006 European Society of Cardiology

Impact of pulmonary regurgitation and right ventricular dysfunction on oxygen uptake recovery kinetics in repaired tetralogy of Fallot

Alessandro Giardinia,*, Salvatore Specchiab, Gloria Coutsoumbasb, Andrea Dontia, Roberto Formigaria, Rossella Fattoric, Guido Oppidoa, Gaetano Gargiuloa and Fernando M. Picchioa

a Pediatric Cardiology and Adult Congenital Unit, University of Bologna, Via Massarenti 9, 40138, Bologna, Italy
b Institute of Cardiology, University of Bologna, Italy
c Division of Radiology, University of Bologna, Italy

* Corresponding author. Tel.: +39 051 6363435; fax: +39-051-6363461. E-mail address: alessandro5574{at}iol.it (A.Giardini).


  Abstract

Background: Patients with repaired tetralogy of Fallot (ToF) featuring severe pulmonary regurgitation (PR) and/or right ventricular (RV) dysfunction have reduced exercise tolerance.

Aims: To assess the impact of PR and of RV function on the ability to recover from exercise in ToF patients.

Methods: 61 consecutive patients aged 23.1±12.1 years underwent maximal cardiopulmonary exercise test (CPX), transthoracic echocardiography and magnetic resonance imaging. This data was compared to those of 153 matched healthy subjects.

Results: 19 patients (31%) had severe PR. RV dysfunction was noted in 19 patients (31%). Nine patients (15%) had both severe PR and RV dysfunction. Patients had lower peak oxygen uptake (VO2), VO2 slope, carbon dioxide production (VCO2) slope and O2 pulse slope (p<0.0001), especially those with severe PR and RV dysfunction (p<0.0001). Heart rate slope was similar between groups. No patient with severe PR and RV dysfunction had a predicted peak VO2>40%. CPX had a high sensitivity and specificity to identify patients with severe PR and RV dysfunction.

Conclusions: In ToF patients, severe PR and RV dysfunction lead to delayed recovery from exercise. CPX can identify patients with severe PR and RV dysfunction and may be useful to guide the pulmonary valve replacement decision-making process.

Key Words: Tetralogy of Fallot • Echocardiography • Cardiopulmonary exercise testing • Congenital heart defects • Magnetic resonance imaging

Received February 25, 2005; Revised November 7, 2005; Accepted January 25, 2006


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