© 2005 European Society of Cardiology
Obese subjects with heart failure have lower N-terminal pro-brain natriuretic peptide plasma levels irrespective of aetiology
a Department of Cardiology, Research Center La Fe Hospital José María Haro, 59, puerta 59, 46022 Valencia, Spain
b Department of Cardiology, Dr. Peset Hospital Valencia, Spain
c Department of Cardiology, San Juan Hospital Alicante, Spain
d Department of Cardiology, Elche Hospital Spain
e Department of Cardiology, General Hospital Valencia, Spain
f Department of Cardiology, La Fe Hospital Valencia, Spain
g Department of Cardiology, General Hospital Alicante, Spain
* Corresponding author. Tel.: +34 96 371 61 98; fax: +34 96 1973018. E-mail address: rivera_jmi{at}gva.es
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Abstract |
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N-terminal pro-brain natriuretic peptide (NT-proBNP) may be useful in the diagnosis of heart failure and ventricular dysfunction. Obesity is an independent cardiovascular risk factor. The purpose of this study was to measure NT-proBNP plasma levels in obese and non-obese subjects with heart failure and to compare levels in subjects with ischaemic and dilated aetiology.
In this study, obese subjects had 63% lower NT-proBNP plasma levels than non-obese subjects (p<0.01). In multivariate analysis, BMI was inversely associated with NT-proBNP plasma levels (p<0.05) and a 17% decrease in natriuretic peptide levels was attributed to obesity (p<0.036). When we analyzed data according to the aetiology of heart failure, we found that both groups (ischaemic and dilated) had a 65% decrease in NT-proBNP plasma levels in obese subjects compared to non-obese subjects.
Received July 2, 2004; Revised January 13, 2005; Accepted April 13, 2005
The research support source was from the National Institute of Health Fondo de Investigaciones Sanitarias del Instituto de Salud Carlos III, FIS 01/0943 Project, Spain.
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