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European Journal of Heart Failure 2005 7(6):1023-1026; doi:10.1016/j.ejheart.2005.06.004
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© 2005 European Society of Cardiology

Ventricular remodeling in Loeffler endocarditis: Implications for therapeutic decision making

Carla Lofiego, Marinella Ferlito, Guido Rocchi, Elena Biagini, Enrica Perugini, Angelo Branzi and Claudio Rapezzi*

Institute of Cardiology, University of Bologna Policlinico S. Orsola-Malpighi, Via Massarenti 9, 40138 Bologna, Italy

* Corresponding author. Tel.: +39 051 349858; fax: +39 051 344859. E-mail address: crapezzi{at}aosp.bo.it


  Abstract

Background: Little is known about the morphological and functional evolution of ventricular abnormalities in Loeffler endocarditis.

Methods and Results: We describe 5 patients, including 3 with long-term echocardiographic follow-up, in whom apical obliteration due to fibro-thrombotic thickening of the endocardium showed favorable patterns of evolution. In one patient there was almost complete resolution of the obliterative process with consequently increased effective ventricular volume. In two patients formation of a flow-passage in the fibrocalcific apical ‘floor’ between the main medioventricular cavity and the apical chamber, leading to a ‘double-chambered’ left ventricle was observed.

Conclusions: Medical therapy and appropriate anticoagulation, can induce favorable long-term ventricular remodeling in Loeffler endocarditis.

Key Words: Loeffler endocarditis • Doppler echocardiography • Thrombosis • Hypereosinophilia • Endomyocardial fibrosis

Received December 25, 2004; Revised May 18, 2005; Accepted June 15, 2005


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