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European Journal of Heart Failure 2005 7(4):520-524; doi:10.1016/j.ejheart.2004.07.011
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© 2005 European Society of Cardiology

Tissue Doppler velocities of mitral annulus and NT-proBNP in patients with heart failure

Martin Tretjaka,*, Franc Verovnika, Davorin Benkoa and Mirta Kozeljb

a Department of Cardiology, General Hospital Slovenj Gradec Gosposvetska 1, 2380 Slovenj Gradec, Slovenia
b Department of Cardiology, University Medical Centre Ljubljana Zaloska 7, 1000 Ljubljana, Slovenia

* Corresponding author. Tel.: +386 2 8823 400; Fax: +386 2 8823 505. E-mail address: martin.tretjak{at}siol.net


  Abstract

Background: It has been shown that pulsed wave tissue Doppler velocities of mitral annulus correlate well with left ventricular (LV) diastolic and systolic functions. It is not yet clear whether these velocities can be used to estimate left ventricular dysfunction in an unselected population of patients with clinical signs and symptoms of heart failure (HF).

Aim: To determine whether LV mitral annulus velocities measured by tissue Doppler imaging (TDI) correlate with plasma N-terminal pro-brain natriuretic peptide (NT-proBNP) levels in patients with HF.

Methods and results: Early diastolic (Em) and systolic (Sm) TDI velocities of septal and lateral mitral annulus were measured in 50 patients with HF together with other conventional echocardiographic parameters, and compared with plasma NT-proBNP levels. Significant correlations were found between NT-proBNP level and Em velocity (r=–0.79), Sm velocity (r=–0.43), early transmitral to Em velocity ratio (r=0.38), LV end diastolic diameter (r=0.29), LV ejection fraction (r=–0.44) and tricuspid regurgitant velocity (r=0.31). In multiple regression model (R2=0.733), the Em velocity was the most important predictor of NT-proBNP level.

Conclusions: Early diastolic mitral annulus velocity measured by TDI correlates strongly with plasma NT-proBNP levels, and provides a simple, accurate and reproducible echocardiographic index of heart failure.

Key Words: Tissue Doppler imaging • Heart failure • NT-proBNP

Received May 4, 2004; Revised June 17, 2004; Accepted July 21, 2004


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