Skip Navigation

European Journal of Heart Failure 2004 6(5):551-554; doi:10.1016/j.ejheart.2003.08.004
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Bussotti, M.
Right arrow Articles by Agostoni, P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Bussotti, M.
Right arrow Articles by Agostoni, P.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 2004 European Society of Cardiology

Exercise-induced changes in exhaled nitric oxide in heart failure

Maurizio Bussotti, Daniele Andreini and Piergiuseppe Agostoni*

Centro Cardiologico Monzino IRCCS, Istituto di Cardiologia Università di Milano via Parea 4, 20138 Milan, Italy

* Corresponding author.E-mail address: Piergiuseppe.Agostoni{at}cardiologicomonzino.it


  Abstract

Background: In heart failure abnormalities of pulmonary function are frequently observed as shown by hyperpnea, reduced lung compliance, reduced alveolar-capillary gas diffusion, positive methacholine challenge and, during exercise, early expiratory flow limitation. Nitric oxide (NO) might be related to all the above abnormalities.

Aims: We evaluated whether a correlation between exhaled NO (eNO) and lung function exists at rest and during exercise in heart failure.

Methods: We studied 33 chronic heart failure patients and 11 healthy subjects with: (a) standard pulmonary function, (b) lung diffusion for carbon monoxide (DLCO) including its subcomponents, capillary volume and membrane resistance and eNO both at rest and during light exercise, (c) maximal cycloergometer cardiopulmonary exercise test.

Results: Forced expiratory volume in 1 s (FEV1) was reduced in heart failure patients (83±17% of predicted), as was DLCO (75±18% of predicted) due to reduced membrane resistance (32.6±10.3 ml mmHg–1 min–1 vs. 39.9±6.9 in patients vs. controls, P<0.02). Exhaled NO was lower in patients vs. controls (9.7±5.4 ppm vs. 14.4±6.4, P<0.05) and was, during exercise, constant in patients and reduced in controls. No significant correlation was found between eNO and lung function. Vice-versa eNO changes during exercise were correlated with peak exercise oxygen consumption (r=0.560, P<0.001).

Conclusions: The hypothesis of a link between eNO and lung function in heart failure was not proved. The correlation between eNO changes during exercise and peak VO2 might be due to hemoglobin oxygenation, which binds NO to hemoglobin.

Key Words: Heart failure • Nitric oxide • Lung diffusion • Exercise

Received January 20, 2003; Revised June 20, 2003; Accepted August 28, 2003


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.