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European Journal of Heart Failure 2004 6(4):375-376; doi:10.1016/j.ejheart.2003.12.017
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© 2004 European Society of Cardiology

Experimental animal model for anthracycline-induced heart failure

Patrick J. Perik, Maarten P. van den Berg, Elisabeth G.E. de Vries and Dirk J. van Veldhuisen

Department of Medical Oncology, University Hospital Groningen The Netherlands
Department of Medical Oncology, University Hospital Groningen The Netherlands
Department of Cardiology, University Hospital Groningen P.O. Box 30001, Thorax centre, Hanzeplein 1, 9700 RB Groningen, The Netherlands
Department of Cardiology, University Hospital Groningen P.O. Box 30001, Thorax centre, Hanzeplein 1, 9700 RB Groningen, The Netherlands

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The paper by Simunek et al. in this issue of the journal describes a rabbit model for heart failure (HF), in which HF is caused by anthracycline-induced cardiomyocyte damage [1]. The discovery of the presence of both apoptosis [2], and proliferation [3] in cardiac myocytes in the human heart, contested the general assumption that the heart is a terminally . . . [Full Text of this Article]


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