© 2004 European Society of Cardiology
Basal and exercise-induced neuroendocrine activation in patients with heart failure and in normal subjects
a Department of Clinical Physiology and Nuclear Medicine, Frederiksberg Hospital University of Copenhagen, Nordre Fasanvej 57, DK-2000 Frederiksberg, Denmark
b Department of Medical Physiology, The Panum Institute University of Copenhagen, Copenhagen, Denmark
c Department of Cardiology E, Frederiksberg Hospital University of Copenhagen, Frederiksberg, Denmark
* Corresponding author. Tel.: +45-3816-4771; fax: +45-3816-4779. E-mail address: kjaer{at}mfi.ku.dk
 |
Abstract |
|---|
Background: Neuroendocrine activation is a pathophysiological response and an important prognostic marker in patients with chronic heart failure (CHF). Although chronic activation is well described, data on the responsiveness of the hormone systems are more limited. Most previous studies have looked at activation during maximal exercise, whereas we believe that activation at a submaximal level might be more pathophysiologically relevant.
Aim: To compare exercise-induced neurohormonal activation between CHF patients and normal subjects using the same relative and submaximal workload.
Subjects: Twenty-three newly-diagnosed CHF patients and 18 age- and gender-matched healthy subjects were exercised at two workloads, which were calculated to correspond to 50 and 75% of each individual's heart rate response.
Results: In CHF patients, baseline levels of ANP, BNP, AVP, PRA and ET-1 were elevated compared to healthy subjects. Exercise induced an increase in ANP, A and NA in both CHF patients and in normal subjects, however BNP was only increased in CHF patients and not in normal subjects.
Conclusion: When CHF patients exercise at the same relative and submaximal level as age-matched healthy subjects, the relative increases in ANP, A and NA were similar, however, BNP levels only increased in the CHF group.
Key Words: Heart failure • Exercise • Atrial natriuretic peptide • Brain natriuretic peptide • Vasopressins • Catecholamines • Adrenaline • Noradrenaline • Renin • Endothelin-1
Received November 12, 2001; Revised October 8, 2002; Accepted January 23, 2003
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  T. J. Vittorio, R. Zolty, M. E. Kasper, R. M. Khandwalla, D. S. Hirsh, C.-H. Tseng, U. P. Jorde, and K. Ahuja Differential Effects of Carvedilol and Metoprolol Succinate on Plasma Norepinephrine Release and Peak Exercise Heart Rate in Subjects With Chronic Heart Failure Journal of Cardiovascular Pharmacology and Therapeutics, March 1, 2008; 13(1): 51 - 57. [Abstract] [PDF]
|
|
|
|
 |
|
 M. Damgaard, J. P. Goetze, P. Norsk, and N. Gadsboll Altered sodium intake affects plasma concentrations of BNP but not proBNP in healthy individuals and patients with compensated heart failure Eur. Heart J., November 2, 2007; 28(22): 2726 - 2731. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Schou, F. Gustafsson, A. Kjaer, and P. R. Hildebrandt Long-term clinical variation of NT-proBNP in stable chronic heart failure patients Eur. Heart J., January 11, 2007; (2007) ehl449v1. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Schou, F. Gustafsson, P. H. Nielsen, L. H. Madsen, A. Kjaer, and P. R. Hildebrandt Unexplained week-to-week variation in BNP and NT-proBNP is low in chronic heart failure patients during steady state Eur J Heart Fail, January 1, 2007; 9(1): 68 - 74. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Schou, M. K. Dalsgaard, O. Clemmesen, E. A. Dawson, C. C. Yoshiga, H. B. Nielsen, F. Gustafsson, P. R. Hildebrandt, and N. H. Secher Kidneys extract BNP and NT-proBNP in healthy young men J Appl Physiol, November 1, 2005; 99(5): 1676 - 1680. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Zicha, M. Fernandez-Velasco, G. Lonardo, N. L'Heureux, and S. Nattel Sinus node dysfunction and hyperpolarization-activated (HCN) channel subunit remodeling in a canine heart failure model Cardiovasc Res, June 1, 2005; 66(3): 472 - 481. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. J Weisbrod, L. F Arnolda, D. J McKitrick, G. O'Driscoll, K. Potter, and D. J Green Vasomotor responses to decreased venous return: effects of cardiac deafferentation in humans J. Physiol., November 1, 2004; 560(3): 919 - 927. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Bruins, M. R. Fokkema, J. W.P. Romer, M. J.L. DeJongste, F. P.L. van der Dijs, J. M.W. van den Ouweland, and F. A.J. Muskiet High Intraindividual Variation of B-Type Natriuretic Peptide (BNP) and Amino-Terminal proBNP in Patients with Stable Chronic Heart Failure Clin. Chem., November 1, 2004; 50(11): 2052 - 2058. [Abstract] [Full Text] [PDF]
|
|