© 2004 European Society of Cardiology
Association of the angiotensin-converting enzyme gene polymorphism with chronic heart failure in Chinese Han patients
a Department of Cardiology, Xiang Ya Hospital Central South University, Changsha, Hunan, PR China
b Human Reproductive Engineering Lab, Xiang Ya Medical College Central South University, Changsha, Hunan, PR China
* Corresponding author. Tel.: +86-731-4804132. E-mail address: hwyswallow{at}163.com
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Abstract |
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Background: An insertion/deletion (I/D) polymorphism is present in the 16th intron of the angiotensin-converting enzyme (ACE) gene and is associated with serum and tissue ACE level. Some studies have shown that the DD genotype is associated with some cardiovascular diseases; while ACE polymorphism's effect on chronic heart failure (CHF) remains uncertain.
Aim: To investigate the association of the ACE gene I/D polymorphism with CHF in the Chinese Han population.
Methods: The genotype was determined by polymerase chain reaction in 102 normal controls and in 79 patients with CHF. Plasma angiotensin (Ang) levels were assessed by radio-immunity assay. Left ventricular end-diastolic diameters (LVDD) and left ventricular ejection fractions were assessed by echocardiography.
Results: The ACE gene polymorphism distribution was similar in patients and control subjects. However, ACE gene DD polymorphism was associated with a more severe condition, greater LVDD [mm: DD: 71±7, ID: 62±5, II: 60±5, P<0.001 DD vs. ID, P<0.001 DD vs. II] and higher plasma Ang II level [pg/ml DD: 92±19, ID: 79±21, II: 65±17 P<0.05 DD vs. ID, P<0.001 DD vs. II].
Conclusion: In Chinese Han patients with CHF, ACE gene DD polymorphism might be a marker of a more severe condition, and a higher level of activation of the renin–angiotensin system.
Key Words: Heart failure • chronic • Peptidyl-dipeptidase A • Gene • Polymorphism
Received October 28, 2002; Revised March 26, 2003; Accepted September 25, 2003
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