© 2004 European Society of Cardiology
A method to reduce loss to follow-up in clinical trials: informed, withdrawal of consent
a Department of Cardiology, University of Hull Castle Hill Hospital, Cottingham, Kingston-upon-Hull, HU15 5JQ, UK
b Department of Cardiology Gentofle University Hospital, Copenhagen, Denmark
c Department of Cardiology Hull Royal Infirmary, Anlaby Road, Kingston-upon-Hull, HU3 2JZ, UK
* Corresponding author. Tel.: +44-1482-624087; fax: +44-1482-624085. E-mail address: g.m.porter@hull.ac.uk
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If a large number of patients are lost to follow up during the course of a clinical trial it can greatly hamper interpretation of the results. Accordingly the proportion of patients lost to follow up is one of the quality indicators for randomised controlled trials.
There are many reasons for loss to follow up. The patient may move to other regions, may disappear, suffer unreported death or the patient may not wish to attend the