© 2003 European Society of Cardiology
D-Ribose improves diastolic function and quality of life in congestive heart failure patients: a prospective feasibility study
a Department of Medicine – Cardiology, University of Bonn Sigmund-Freud-Street 25, D 53105 Bonn, Germany
b Bioenergy, Inc. Ham Lake, MN, USA
* Corresponding author. Tel.: +49-228-287-6784; fax: +49-228-287-6423. E-mail address: omran{at}uni-bonn.de
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Abstract |
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Patients with chronic coronary heart disease often suffer from congestive heart failure (CHF) despite multiple drug therapies. D-Ribose has been shown in animal models to improve cardiac energy metabolism and function following ischaemia. This was a prospective, double blind, randomized, crossover design study, to assess the effect of oral D-ribose supplementation on cardiac hemodynamics and quality of life in 15 patients with chronic coronary artery disease and CHF. The study consisted of two treatment periods of 3 weeks, during which either oral D-ribose or placebo was administered followed by a 1-week wash out period, and then administration of the other supplement. Assessment of myocardial functional parameters by echocardiography, quality of life using the SF-36 questionnaire and functional capacity using cycle ergometer testing was performed. The administration of D-ribose resulted in an enhancement of atrial contribution to left ventricular filling (40±11 vs. 45±9%, P=0.02), a smaller left atrial dimension (54±20 vs. 47±18 ml, P=0.02) and a shortened E wave deceleration (235±64 vs. 196±42, P=0.002) by echocardiography. Further, D-ribose also demonstrated a significant improvement of the patient's quality of life (417±118 vs. 467±128, P
0.01). In comparison, placebo did not result in any significant echocardiographic changes or in quality of life. This feasibility study in patients with coronary artery disease in CHF revealed the beneficial effects of D-ribose by improving diastolic functional parameters and enhancing quality of life.
Key Words: Coronary artery disease • Heart failure • Ribose • Quality of life
Received August 21, 2002; Revised November 25, 2002; Accepted January 7, 2003
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