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European Journal of Heart Failure 2003 5(2):161-163; doi:10.1016/S1388-9842(02)00238-6
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© 2002 European Society of Cardiology

Tumor necrosis factor-{alpha} polymorphism in Turkish patients with dilated cardiomyopathy

Mehmet Alikasifoglua, Lale Tokgözoglub,*, Tayfun Acilb, Enver Atalarb, Mehmet Ali Otob, Süleyman Sirri Kesb and Ergül Tuncbileka

a Faculty of Medicine, Department of Pediatrics, Division of Genetic Diseases, Hacettepe University Ankara, Turkey
b Hacettepe University, Faculty of Medicine, Department of Cardiology Ankara, Turkey

* Corresponding author. Kuveyt caddesi No. 9, 06540 Kavaklidere, Ankara, Turkey. Tel.: +90-312-4683013; fax: +90-312-4661906 E-mail address: mehmet@gen.hun.edu.tr lalet@bim.net.tr tacil@lycos.com enveratalar@hotmail.com alioto@superonline.com

Received May 14, 2002; Revised August 7, 2002; Accepted September 17, 2002

The first 10% of the full text of this article appears below.


   1. Background
 
Tumor necrosis factor-{alpha} (TNF-{alpha}) is a proinflammatory cytokine with pleiotropic biological effects. Numerous studies have indicated a role of TNF-{alpha} in the pathophysiology of congestive heart failure [1–4]. Since genetic polymorphisms in the TNF locus were known to be related to several autoimmune, infectious, and neoplastic diseases [5], the association between TNF-{alpha} gene polymorphism and dilated cardiomyopathy (DCM) was also studied [6–8]. However, the results obtained were contradictory. Studies done in patients with different ethnic origins yielded contrasting results [6,7].


   2. Aims
 
. . . [Full Text of this Article]


   3. Methods
 
3.1. Serum samples and analysis of the TNF-{alpha} gene polymorphisms
3.2. Statistical analysis

   4. Results
 

   5. Conclusion
 

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