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European Journal of Heart Failure 2002 4(6):719-726; doi:10.1016/S1388-9842(02)00170-8
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© 2002 European Society of Cardiology

Acute haemodynamic effects of oestrogen administration in male patients with chronic heart failure

Stamatis Adamopoulos, Dionyssios Leftheriotis*, Eftihia Sbarouni, George Karavolias and Dimitrios Th Kremastinos

Second Department of Cardiology, Onassis Cardiac Surgery Centre 356 Syngrou Avenue, 176 74 Athens, Greece

* Corresponding author. Tel.: +30-1-9493-372/000; fax: +30-1-9493-373. E-mail address: elbee{at}ath.forthnet.gr


  Abstract

Background: Although there are many studies concerning the effects of long-term oestrogen administration on systemic haemodynamics in postmenopausal women, the effects of oestrogen in patients with chronic heart failure are not defined.

Aim: The goal of this study was to evaluate the acute haemodynamic effects of oestrogen in male patients with chronic heart failure.

Methods and results: We studied 15 men with advanced heart failure (NYHA II–IV, EF<35=). A Swan–Ganz thermodilution catheter was advanced in their pulmonary artery and central haemodynamics were assessed at baseline, after placebo administration, and following 0.625 and 1.25 mg of oestrogen infusion. Simultaneously, all patients underwent limb plethysmography. Analysis of variance with repeated measures was used to compare the sequential measurements. Following oestrogen administration, right atrial, pulmonary artery and pulmonary capillary wedge pressures, as well as systemic, pulmonary and forearm vascular resistance were decreased; cardiac output, cardiac index, stroke volume, stroke volume index, stroke work index and forearm blood flow were increased.

Conclusions: In male patients with chronic heart failure, acute oestrogen administration improves the indices of cardiac systolic performance and decreases pulmonary and systemic vascular resistance. These findings imply a beneficial effect of oestrogen in selected patients with chronic heart failure.

Key Words: Oestrogen • Heart failure • Acute effect • Haemodynamics

Received October 11, 2001; Revised July 22, 2002; Accepted July 23, 2002


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