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European Journal of Heart Failure 2002 4(5):587-591; doi:10.1016/S1388-9842(02)00088-0
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© 2002 European Society of Cardiology

Myocardial lactate dehydrogenase patterns in volume or pressure overloaded left ventricles

Cornelia Pipera,*, Dieter Horstkottea, Anne-Katrin Bockb, Edmund Wudelc, Heinz-Peter Schultheißb and Andrea Dörnerb

a Department of Cardiology, Heart Center North Rhine-Westphalia, Ruhr University of Bochum Georgstrasse 11, 32545 Bad Oeynhausen, Germany
b Department of Cardiology, Benjamin Franklin Hospital, Free University of Berlin Berlin, Germany
c Department of Diagnostic Radiology and Nuclear Medicine, Benjamin Franklin Hospital, Free University of Berlin Berlin, Germany

* Corresponding author. Tel.: +49-5731-971258; fax: +49-5731-972194. E-mail address: cpiper@hdz-nrw.de

Received August 2, 2001; Revised October 25, 2001; Accepted January 17, 2002

The first 150 words of the full text of this article appear below.


   1. Background
 
In patients with left ventricular hypertrophy [1–4] and congestive heart failure [5–9] myocardial energy metabolism is adapted to the chronic burden. The pyridine nucleotide redox system (NAD/NADH system) is a sensitive indicator for the functional status of cellular oxidation [2,10]. As the NAD/NADH system is closely linked with the lactate dehydrogenase system the latter can be used to evaluate the NAD/NADH system and thus the myocardial energy status [11]. Myocardial lactate dehydrogenase activity and isoenzyme patterns can be considered a sensitive method to analyze changes of the enzyme status in patients with various heart diseases [7,12,13].


   2. Aims
 
We assessed myocardial LDH activity and LDH isoenzyme pattern of patients with aortic stenosis, aortic or mitral regurgitation, analyzed whether severity of left ventricular volume or pressure overload correlates with severity of myocardial dysfunction, and whether the LDH system can be . . . [Full Text of this Article]


   3. Methods and results
 
3.1. Patients
3.2. Gated equilibrium blood pool imaging
3.3. Cardiopulmonary exercise
3.4. Assessment of myocardial lactate dehydrogenase activity
3.5. Gel electrophoresis
3.6. Statistical analysis

   4. Results
 

   5. Conclusion
 

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