© 2001 European Society of Cardiology
Growth hormone alone or combined with metoprolol preserves cardiac function after myocardial infarction in rats
a Wallenberg Laboratory, Sahlgrenska University Hospital SE-41345 Göteborg, Sweden
b Department of Cardiology, Sahlgrenska University Hospital SE-41345 Göteborg, Sweden
c Department of Pathology, Sahlgrenska University Hospital SE-41345 Göteborg, Sweden
d Department of Clinical Physiology, Sahlgrenska University Hospital SE-41345 Göteborg, Sweden
e Department of Internal Medicine, Research Center for Endocrinology and Metabolism, Gröna Stråket 8, Sahlgrenska University Hospital SE-41345 Göteborg, Sweden
* Corresponding author. Tel.: +46-31-342-4972; fax: +46-31-82-1524. E-mail address: entela.bollano{at}wlab.wall.gu.se (J. Isgaard).
 |
Abstract |
|---|
Background and objective: Beta-adrenoreceptor blocking agents are important for the treatment of myocardial infarction (MI). Accumulating evidence also indicates that growth hormone (GH) improves cardiac function after MI in rats. We aimed to investigate the cardiovascular effects of combined treatment in an animal model of MI.
Methods: MI was induced in rats by ligation of the left coronary artery. Three days after MI, animals were randomly assigned to one of four groups: controls (C) (n=19); GH (n=19) receiving s.c. 2 mg/kg per day rhGH; metoprolol (M) group (n=19) receiving 24 mg/kg per day and combined group (GHM) (n=20) treated with both GH (2 mg/kg per day s.c.) and M (24 mg/kg per day) for 9 days. Transthoracic echocardiography was performed before and after treatment.
Results: Serum levels of insulin-like growth factor I were significantly elevated in the GH-group but not in the GHM group compared to controls. Left ventricular volumes, cardiac index, systolic blood pressure, were similar in all groups. Percent changes in ejection fraction compared to baseline were; GH (6.1±5.0%) and GHM (6.1±4.2%) vs. C (–12.5±3.0%), P<0.01, M (–7.3±4.2%). The occurrence of aneurysms was not significantly different between the various treatment regimes.
Conclusion: Treatment with growth hormone alone or in combination with metoprolol preserved left ventricular function after MI.
Key Words: Left ventricular remodeling • Growth hormone • Metoprolol • Aneurysm
Received December 15, 2000; Revised February 13, 2001; Accepted April 26, 2001
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  L. H. Lund, P. Freda, J. J. Williams, J. J. LaManca, T. H. LeJemtel, and D. M. Mancini Growth hormone resistance in severe heart failure resolves after cardiac transplantation Eur J Heart Fail, May 1, 2009; 11(5): 525 - 528. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B.-q. Zhu, U. Simonis, G. Cecchini, H.-z. Zhou, L. Li, J. R. Teerlink, and J. S. Karliner Comparison of Pyrroloquinoline Quinone and/or Metoprolol on Myocardial Infarct Size and Mitochondrial Damage in a Rat Model of Ischemia/Reperfusion Injury Journal of Cardiovascular Pharmacology and Therapeutics, June 1, 2006; 11(2): 119 - 128. [Abstract] [PDF]
|
|
|
|
 |
|
 S. Marleau, M. Mulumba, D. Lamontagne, and H. Ong Cardiac and peripheral actions of growth hormone and its releasing peptides: Relevance for the treatment of cardiomyopathies Cardiovasc Res, January 1, 2006; 69(1): 26 - 35. [Abstract] [Full Text] [PDF]
|
|