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European Journal of Heart Failure 2001 3(1):27-32; doi:10.1016/S1388-9842(00)00116-1
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© 2001 European Society of Cardiology

Increased nitric oxide in exhaled air in patients with rheumatic heart disease

Zehra Gölbasla,*, Sibel Dinçerb, Hakan Bayola, Belgizar Ugurlub, Dilek Çiçeka, Telat Kelesa, Sinan Aydogdua and Deniz Erbasb

a Department of Cardiology, Ankara Numune Education and Research Hospital Ankara, Turkey
b Department of Physiology, Gazi University Medical Faculty Ankara, Turkey

* Corresponding author. Tel.: +90-31-2310-3030/+90-31-2310-3635; fax: +90-31-2310-3460. E-mail address: golbasiz{at}anh.gov.tr (Z. Gölbas1).


  Abstract

Background: Endogenous production of nitric oxide and its presence in exhaled air was observed in humans. Prior studies have yielded contrasting information about the production of nitric oxide in patients with heart failure.

Aims: The aim of this study was to measure nitric oxide in the exhaled air of patients with chronic rheumatic heart disease with and without pulmonary hypertension.

Methods: Seventy-four patients (6 patients had isolated mitral stenosis; 13 patients had combined mitral stenosis and mitral regurgitation; 1 patient had isolated mitral regurgitation; 54 patients had combined mitral and aortic valve disease) and 27 healthy subjects were entered in the study. The nitric oxide concentration in exhaled air was determined with a chemiluminescence analyser. Echocardiography was performed in all patients to assess the severity of the valve disease and for the measurement of pulmonary artery pressure.

Results: The level of exhaled nitric oxide was significantly greater in patients with rheumatic heart disease than in controls. The value of nitric oxide concentration in exhaled air was significantly increased in patients with pulmonary hypertension, as compared with patients who had normal pulmonary artery systolic pressure.

Conclusion: We found increased nitric oxide in the exhaled air in patients with rheumatic heart disease, especially in those with pulmonary hypertension, compared with healthy patients.

Key Words: Nitric oxide • Heart failure • Rheumatic heart disease • Pulmonary hypertension

Received January 4, 2000; Revised April 20, 2000; Accepted June 20, 2000


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