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European Journal of Heart Failure Advance Access originally published online on April 6, 2009
European Journal of Heart Failure 2009 11(6):551-558; doi:10.1093/eurjhf/hfp043
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Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2009. For permissions please email: journals.permissions@oxfordjournals.org.

Plasma apelin concentration is depressed following acute myocardial infarction in man

Robin A.P. Weir1,*, Kwok Shiong Chong1, Jonathan R. Dalzell1, Colin J. Petrie1, Charles A. Murphy1, Tracey Steedman1, Patrick B. Mark1, Theresa A. McDonagh2, Henry J. Dargie1 and John J.V. McMurray1

1 Cardiology Department, Western Infirmary, Glasgow G11 6NT, Scotland, UK
2 Cardiology Department, Royal Brompton Hospital, London SW3 6NP, UK

* Corresponding author. Tel: +44 141 211 8527, Fax: +44 141 211 1791, Email: robinweir75{at}hotmail.com


  Abstract

Aims: Apelin, a novel peptide with a putative role in cardiovascular homeostasis, has gained interest as an endogenous inotrope, but has yet to be described following acute myocardial infarction (AMI) in man. We aimed to characterize plasma apelin concentrations following AMI and to examine its relationship with clinical and prognostic biomarkers.

Methods and results: Plasma concentrations of apelin, N-terminal probrain natriuretic peptide (NT-proBNP), norepinephrine, and arginine vasopressin were measured in 100 patients [mean age 58.9 ± 12 (SD) years, 77% male] admitted with AMI, with echocardiographic left ventricular (LV) ejection fraction <40%, at mean 46 h after admission and at 24 weeks. Cardiac magnetic resonance imaging was performed pre-discharge and at 24 weeks. Thirty-eight subjects with no cardiac history acted as controls. Apelin concentration was reduced early after AMI (0.54 ± 0.25 vs. 3.22 ± 3.01 ng/mL, P <0.001) and remained low at 24 weeks, although it did increase significantly from baseline to 0.62 ± 0.36 ng/mL, P = 0.030. Apelin had no relationship with any parameter of LV function over time. A relationship was found between baseline apelin and norepinephrine (r = 0.26, P = 0.008). Both NT-proBNP and norepinephrine correlated with adverse ventricular function after AMI.

Conclusion: Plasma apelin concentration is reduced early after AMI, increases significantly over time, but remains depressed at 24 weeks.

Key Words: Apelin • Myocardial infarction • Cardiac magnetic resonance • Peptide hormones • Eplerenone

Received November 19, 2008; Revised February 5, 2009; Accepted February 16, 2009


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