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European Journal of Heart Failure Advance Access originally published online on March 30, 2009
European Journal of Heart Failure 2009 11(5):453-462; doi:10.1093/eurjhf/hfp037
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Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2009. For permissions please email: journals.permissions@oxfordjournals.org.

Alcohol abuse and heart failure

Irma Laonigro1, Michele Correale2,*, Matteo Di Biase2 and Emanuele Altomare1

1 Department of Medical and Occupational Sciences, Institute of Internal Medicine, University of Foggia, Foggia, Italy
2 Department of Cardiology, ‘Ospedali Riuniti’ OO.RR, University of Foggia, viale L Pinto, 1, 71100 Foggia, Italy

* Corresponding author. Tel: +39 0881733652, Fax: +39 0881745424, Email: opsfco{at}tin.it


  Abstract

Alcoholic patients who consume >90 g of alcohol a day for >5 years are at risk of developing asymptomatic alcoholic cardiomyopathy (ACM). Those patients who continue to drink may become symptomatic and develop signs and symptoms of heart failure (HF). This distinct form of congestive HF is responsible for 21–36% of all cases of non-ischaemic dilated cardiomyopathy in Western Society. Without complete abstinence, the 4 year mortality for ACM is close to 50%. This short review summarizes the experimental and clinical evidence regarding the role of alcohol in the pathophysiology of ACM and HF.

Key Words: Alcoholic cardiomyopathy • Heart failure • Congestive heart failure

Received September 5, 2008; Revised January 5, 2009; Accepted February 6, 2009


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