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European Journal of Heart Failure 2008 10(6):556-559; doi:10.1016/j.ejheart.2008.04.012
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© 2008 European Society of Cardiology

Serum carbohydrate antigen 125 levels in advanced heart failure: Relation to B-type natriuretic peptide and left atrial volume

Dursun Dumana,*, Fatih Palitb, Ergun Simsekb and Karadag Bilgehanc

a Haydarpasa Numune Training and Research Hospital, Department of Cardiology, Tibbiye Caddesi Kadiköy/Istanbul, Turkey
b Haydarpasa Numune Training and Research Hospital, Department of Internal Medicine Istanbul, Turkey
c University of Istanbul, Cerrahpasa School of Medicine, Department of Cardiology Istanbul, Turkey

* Corresponding author. Tel.: +90 216 640 2061; fax: +90 216 640 2713. E-mail address: drduman{at}excite.com


  Abstract

Aims: To assess the relation between serum levels of carbohydrate antigen 125 (CA 125) and parameters of left ventricular (LV) filling pressure in patients with advanced heart failure (AHF).

Methods: Forty-nine patients (mean age 67±10 years) with LV ejection fraction (EF) ≤0.35 and New York Heart Association (NYHA) class III or IV symptoms of heart failure were enrolled. Left atrial volume indexed to body surface area (LAVI) and the ratio of mitral inflow early diastolic velocity to annulus velocity (E/e) were evaluated with pulsed wave and tissue Doppler. Plasma B-type natriuretic peptide (BNP) was also measured.

Results: The median overall CA 125 value was 44.0 (17.7–140) U/ml. CA 125 above the normal value (<35U/ml) was found in 28 of the 49 patients (57%). Compared to patients with normal CA 125 levels, those with elevated CA 125 had a higher NYHA class and increased serum BNP levels, LAVI and E/e. In multivariate analysis, serum CA 125 levels were significantly associated with BNP (standardized β coefficient=0.58, p<0.001) and LAVI (standardized β coefficient 0.34, p<0.005).

Conclusion: Our study demonstrates that elevated serum CA 125 levels are associated with increased LAVI in parallel to increased neurohormonal activation in patients with AHF.

Key Words: Carbohydrate antigen 125 • Left atrial volume • B-type natriuretic peptide • Advanced heart failure

Received February 16, 2008; Revised April 8, 2008; Accepted April 28, 2008


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