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European Journal of Heart Failure 2008 10(4):373-379; doi:10.1016/j.ejheart.2008.02.011
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© 2008 European Society of Cardiology

Plasma connective tissue growth factor is a novel potential biomarker of cardiac dysfunction in patients with chronic heart failure

Norimichi Koitabashia, Masashi Araia,*, Kazuo Niwanoa, Atai Watanabea, Michiko Endoha, Masahiko Sugutaa, Tomoyuki Yokoyamab, Hiroshi Tadac, Takuji Toyamac, Hitoshi Adachic, Shigeto Naitoc, Shigeru Oshimac, Takashi Nishidad, Satoshi Kubotad, Masaharu Takigawad and Masahiko Kurabayashia

a Department of Medicine and Biological Science, Gunma University Graduate School of Medicine Japan
b Department of Laboratory Science, Gunma University School of Health Science Japan
c Division of Cardiology, Gunma Prefectural Cardiovascular Center Japan
d Department of Biochemistry and Molecular Dentistry, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences Japan

* Corresponding author. Department of Medicine and Biological Science, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi, Gunma, 371-8511, Japan. Tel.: +81 27 220 8142; fax: +81 27 220 8158. E-mail address: araim{at}showa.gunma-u.ac.jp (M. Arai).


  Abstract

Background: Connective tissue growth factor (CTGF) has been recently reported as a mediator of myocardial fibrosis; however, the significance of plasma CTGF concentration has not been evaluated in patients with heart failure. The aim of this study was to investigate the clinical utility of plasma CTGF concentration for the diagnosis of heart failure.

Methods and results: We evaluated fifty-two patients with chronic heart failure. The plasma concentration of CTGF and other markers of fibrosis were assessed and compared with clinical and echocardiographic data. Plasma CTGF was significantly elevated in symptomatic patients in proportion to their NYHA classes and was significantly correlated with plasma brain natriuretic peptide (BNP) concentration (r = 0.395, P < 0.01). Plasma CTGF was also correlated with plasma transforming growth factor beta (TGF-β) (r = 0.512, P < 0.01), matrix metalloproteinase (MMP)-2 (r = 0.391, P < 0.05) and tissue inhibitor of MMP (TIMP)-2 (r = 0.354, P < 0.05) concentrations. Interestingly, plasma CTGF was correlated with E/E' value evaluated by tissue Doppler echocardiography (r = 0.593, P = 0.012), but not with systolic function and left ventricular mass.

Conclusion: Our study suggests that plasma CTGF concentration is a novel diagnostic marker for cardiac dysfunction and may provide additional specific information about myocardial fibrosis in chronic heart failure patients.

Key Words: Cytokines • Ventricular remodeling • Extracellular matrix • Natriuretic peptide

Received July 3, 2007; Revised December 14, 2007; Accepted February 20, 2008


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