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European Journal of Heart Failure 2008 10(3):224-225; doi:10.1016/j.ejheart.2008.01.012
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© 2008 European Society of Cardiology

Can B-type natriuretic peptides replace heart failure risk models?

Wayne C. Levy

University of Washington, Division of Cardiology Box 356422, 1959 NE Pacific Street, Seattle, WA 98195, United States E-mail address: levywc@u.washington.edu. Tel.: +1 206 221 4507; fax: +1 206 221 6835.

Received December 10, 2007;
The first 10% of the full text of this article appears below.

The article by Dr. Pfister and colleagues published in this issue of the European Journal of Heart Failure, compares the prognostic value of the biomarker NT-proBNP and glomerular filtration rate (GFR) with the multivariate CHARM CV morbidity and mortality model and the Seattle Heart Failure Model (SHFM) [1]. The authors found that NT-proBNP was a very powerful risk marker with a hazard ratio of 2.1 for 1 SD increase in log NT-proBNP with a 1-year ROC of 0.80.

However, the group of heart failure patients evaluated was unusual; 65% were evaluated at hospital discharge and 68% of these were NYHA 1 or 2. In addition, the . . . [Full Text of this Article]


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