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European Journal of Heart Failure 1999 1(2):187-190; doi:10.1016/S1388-9842(99)00013-6
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© 1999 European Society of Cardiology

Intravenous L-arginine reduces VE/VCO2 slope acutely in patients with severe chronic heart failure

Adrian P. Banning* and Bernard Prendergast

Department of Cardiology University Hospital of Wales, Heath Park, Cardiff, CF4 4XN, UK

* Corresponding author. Department of Cardiology, John Radcliffe Hospital, Oxford, OX3 9DU, UK. Tel.: +44-1865-741166; fax: +44-1865-220252.

Key Words: Exeruse ventilation • VE/VCO2 slope • Nitrix oxide • L-arginine • Heart failure

Accepted February 26, 1999

The first 10% of the full text of this article appears below.


   1. Background
 
Despite treatment, some patients with chronic heart failure syndrome (CHF) experience persistent exertional breathlessness during exercise. This in part reflects an increased ventilatory cost of CO2 excretion (the linear VE/VCO2 slope) [1]and impaired ventilation and perfusion matching. Patients with CHF have endothelial dysfunction of systemic arteries which may be partially reversed by administration of oral L-arginine [2](substrate for endothelial nitric oxide, NO). There is also evidence of abnormal NO responses in pulmonary arteries in a canine model of heart failure [3]. Therefore, we hypothesised that abnormalities in pulmonary endothelial function in . . . [Full Text of this Article]


   2. Aims
 

   3. Methods
 

   4. Results
 

   5. Conclusions
 

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