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European Journal of Heart Failure 1999 1(2):133-137; doi:10.1016/S1388-9842(99)00025-2
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© 1999 European Society of Cardiology

Treatment of arrhythmias in heart failure

Peter A. O'Callaghan* and A. John Camm

Department of Cardiological Sciences, St George's Hospital Medical School Cranmer Terrace, London SW17 ORE, UK

* Corresponding author. Tel.: +44-181-725-5916; fax: +44-181-767-7141 e-mail: pocallag@sghms.ac.uk

Key Words: Arrhythmia • Antiarrhythmia agents • Heart failure • Death, sudden • Defibrillation

Accepted April 7, 1999

The first 150 words of the full text of this article appear below.


    1. Introduction
 
The last decade has seen major advances in the treatment of congestive heart failure and left ventricular systolic dysfunction. Nevertheless, despite conventional medical therapy including diuretics, digoxin, and angiotensin converting enzyme (ACE) inhibitors, the mortality rate associated with this condition remains unacceptably high, in the range of 5–15% annually in mild heart failure and increasing to 20–50% annually in patients with severe heart failure [1]. Angiotensin-converting enzyme (ACE) inhibitors reduce total mortality in patients with cardiac failure but in most trials do not reduce the frequency of ventricular arrhythmias or sudden cardiac death [2,3]. Sudden cardiac death is responsible for approximately half of all cardiac deaths in patients with heart failure. Sudden and unexpected death accounts for the majority of deaths in mild heart failure; in contrast death due to progressive pump failure accounts for the majority of deaths in severe heart failure (. . . [Full Text of this Article]


    2. Secondary prevention of life-threatening ventricular tacyhyarrhythmias
 
2.1. The decline of pharmacologic therapy
2.2. The rise of device therapy

    3. Primary prevention of sudden cardiac death
 
3.1. Risk stratification and primary prevention

    4. Conclusion
 

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