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European Journal of Heart Failure 2007 9(8):855; doi:10.1016/j.ejheart.2007.06.007
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© 2007 European Society of Cardiology

Tako-Tsubo cardiomyopathy: Authors response to letter from DL Brutsaert

Satoshi Kurisu*

Department of Cardiology, Hiroshima City Hospital 7-33, Moto-machi, Naka-ku, Hiroshima, 730-8518, Japan

* Tel.: +81 82 221 2291; fax: +81 82 223 1447 E-mail address: skurisu{at}nifty.com.

Received June 15, 2007; We appreciate the comments and suggestions of Dr. Brutsaert regarding our report. He speculated that catecholamine-induced endocardial endothelial dysfunction could affect the apical trabeculated left ventricular wall with the highest surface-to-volume ratio preferentially in patients with Tako-Tsubo cardiomyopathy.

This is an exciting mechanism that can explain why left ventricular wall motion abnormality is localized to the apical zone. However, recent reports have demonstrated atypical forms of Tako-Tsubo cardiomyopathy exhibiting mid-ventricular akinesia with apical and basal normokinesia [1]. According to these reports, clinical characteristics seem to be similar between typical and atypical forms of Tako-Tsubo cardiomyopathy. A Japanese group demonstrated a rare case that had both typical and atypical forms of Tako-Tsubo cardiomyopathy sequentially [2]. I think that these phenomena can not be explained only by the above-mentioned mechanism. Moreover, it remains unclear why this disorder occurs predominantly in elderly females.

Further clinical and experimental studies are necessary to clarify the precise mechanism of Tako-Tsubo cardiomyopathy.


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  1. Robles P., Alonso M., Huelmos A.I., Jimenez J.J., Lopez Bescos L. Images in cardiovascular medicine. Atypical transient left ventricular ballooning without involvement of apical segment. Circulation (2006) 113:e686–e688.[Free Full Text]
  2. Abe M., Morisaki M., Kurihara M., et al. A case of ampulla cardiomyopathy, which recurred three times with multi-form asynergy. Shinzo (2004) 36:21–29. [in Japanese].

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This Article
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