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European Journal of Heart Failure 2009 11(2):111-112; doi:10.1093/eurjhf/hfn039
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Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2009. For permissions please email: journals.permissions@oxfordjournals.org.

Inflammation in chronic heart failure: what is familiar, what is unfamiliar?

Michael Fu*

Department of Clinical and Molecular Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Göteborg, Sweden

* Corresponding author: Department of Medicine, Sahlgrenska University Hospital/Sahlgrenska, SE 413 45 Göteborg, Sweden. Tel: +46 31 342 1000, Fax: +46 31 823762, Email: Michael.fu@wlab.gu.se

This editorial refers to ‘Inflammation as a therapeutic target in heart failure? A scientific statement from the Translational Research Committee of the Heart Failure Association of the European Society of Cardiology’{dagger} by Stephane Heymans et al., on page 119 and ‘Immunological mechanisms of pentoxifylline in chronic heart failure’{ddagger} by Steven Shaw et al., on page 113

The first 10% of the full text of this article appears below.


    Introduction
 
Inflammation is commonly observed in patients with chronic heart failure (CHF), and portends a worsening functional capacity and poorer prognosis. The recognition of inflammation as a common, important, and treatable condition in CHF has contributed to intensified research for an effective anti-inflammatory therapy in CHF. However, when sequential multicentre placebo-controlled studies1–5 failed to show any clinical benefit, it became uncertain whether anti-inflammatory therapy really does influence CHF outcome. We may, in fact, wonder what is . . . [Full Text of this Article]


    What is familiar?
 

    What is unfamiliar?
 

    Two comprehensive reviews in this issue
 

    Why research on inflammation should continue despite failed clinical trials?
 

    Summary
 

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Related articles in Eur J Heart Fail:

Immunological mechanisms of pentoxifylline in chronic heart failure
Steven M. Shaw, Mohammed K.H. Shah, Simon G. Williams, and James E. Fildes
Eur J Heart Fail 2009 11: 113-118. [Abstract] [Full Text]  

Inflammation as a therapeutic target in heart failure? A scientific statement from the Translational Research Committee of the Heart Failure Association of the European Society of Cardiology
Stephane Heymans, Emilio Hirsch, Stefan D. Anker, Pal Aukrust, Jean-Luc Balligand, Jan W. Cohen-Tervaert, Helmut Drexler, Gerasimos Filippatos, Stephan B. Felix, Lars Gullestad, Denise Hilfiker-Kleiner, Stefan Janssens, Roberto Latini, Gitte Neubauer, Walter J. Paulus, Burkert Pieske, Piotr Ponikowski, Blanche Schroen, Heinz-Peter Schultheiss, Carsten Tschöpe, Marc Van Bilsen, Faiez Zannad, John McMurray, and Ajay M. Shah
Eur J Heart Fail 2009 11: 119-129. [Abstract] [Full Text]