Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2009. For permissions please email: journals.permissions@oxfordjournals.org.
Inflammation in chronic heart failure: what is familiar, what is unfamiliar?
Department of Clinical and Molecular Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Göteborg, Sweden
* Corresponding author: Department of Medicine, Sahlgrenska University Hospital/Sahlgrenska, SE 413 45 Göteborg, Sweden. Tel: +46 31 342 1000, Fax: +46 31 823762, Email: Michael.fu@wlab.gu.se
This editorial refers to Inflammation as a therapeutic target in heart failure? A scientific statement from the Translational Research Committee of the Heart Failure Association of the European Society of Cardiology
by Stephane Heymans et al., on page 119 and Immunological mechanisms of pentoxifylline in chronic heart failure
by Steven Shaw et al., on page 113
| The first 10% of the full text of this article appears below. |
| Introduction |
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Inflammation is commonly observed in patients with chronic heart failure (CHF), and portends a worsening functional capacity and poorer prognosis. The recognition of inflammation as a common, important, and treatable condition in CHF has contributed to intensified research for an effective anti-inflammatory therapy in CHF. However, when sequential multicentre placebo-controlled studies1–5 failed to show any clinical benefit, it became uncertain whether anti-inflammatory therapy really does influence CHF outcome. We may, in fact, wonder what is
| What is familiar? |
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| What is unfamiliar? |
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| Two comprehensive reviews in this issue |
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| Why research on inflammation should continue despite failed clinical trials? |
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| Summary |
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Related articles in Eur J Heart Fail:
- Immunological mechanisms of pentoxifylline in chronic heart failure
- Steven M. Shaw, Mohammed K.H. Shah, Simon G. Williams, and James E. Fildes
Eur J Heart Fail 2009 11: 113-118.[Abstract] [Full Text] - Inflammation as a therapeutic target in heart failure? A scientific statement from the Translational Research Committee of the Heart Failure Association of the European Society of Cardiology
- Stephane Heymans, Emilio Hirsch, Stefan D. Anker, Pal Aukrust, Jean-Luc Balligand, Jan W. Cohen-Tervaert, Helmut Drexler, Gerasimos Filippatos, Stephan B. Felix, Lars Gullestad, Denise Hilfiker-Kleiner, Stefan Janssens, Roberto Latini, Gitte Neubauer, Walter J. Paulus, Burkert Pieske, Piotr Ponikowski, Blanche Schroen, Heinz-Peter Schultheiss, Carsten Tschöpe, Marc Van Bilsen, Faiez Zannad, John McMurray, and Ajay M. Shah
Eur J Heart Fail 2009 11: 119-129.[Abstract] [Full Text]