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European Journal of Heart Failure 2009 11(11):1031-1035; doi:10.1093/eurjhf/hfp134
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Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2009. For permissions please email: journals.permissions@oxfordjournals.org.

The role of Lamin A/C mutations in Danish patients with idiopathic dilated cardiomyopathy

Daniel Vega Møller1,*, Tam Thanh Pham2, Finn Gustafsson1, Paula Hedley2, Mads Kristian Ersbøll1, Henning Bundgaard1, Claus B. Andersen3, Christian Torp-Pedersen4, Lars Køber1 and Michael Christiansen2

1 Department of Cardiology, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, 2100 Copenhagen O, Denmark
2 Department of Clinical Biochemistry and Immunology, Statens Serum Institut, Copenhagen, Denmark
3 Department of Pathology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
4 Department of Cardiology, Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark

* Corresponding author. Tel: +45 3268 3529, Fax: +45 35452549, Email: dvega@gmx.net

Received April 29, 2009; Revised July 22, 2009; Accepted August 26, 2009

The first 10% of the full text of this article appears below.


   Background
 
Idiopathic dilated cardiomyopathy is characterized primarily by left ventricular dilatation and impaired function. More than 25 genes have been shown to be associated with IDC1,2; however, with the exception of the Lamin A/C (LMNA) gene, each of these genes accounts for <2% of cases. Idiopathic dilated cardiomyopathy caused by LMNA mutations is often accompanied by conduction disorders, cardiac arrhythmias, and/or discrete muscle disorders.3,4 The LMNA gene consists of 12 exons and encodes the intermediate filament proteins Lamin A and C, which maintain the structural integrity of the nuclear envelope and organize chromatin within the nucleus, thereby influencing DNA transcription.5–7


   Aim
 
To examine a Danish IDC cohort for mutations in the LMNA gene, to assess the extent to which the mutation contributes to the disease . . . [Full Text of this Article]


   Methods
 
Subjects
Molecular genetic studies

   Results
 

   Discussion
 

   Funding
 

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