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European Journal of Heart Failure Advance Access published online on November 25, 2009

European Journal of Heart Failure, doi:10.1093/eurjhf/hfp166
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Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2009. For permissions please email: journals.permissions@oxfordjournals.org.

Possible acute and chronic synergistic effect of dual chamber pacing and disopyramide in obstructive hypertrophic cardiomyopathy: a case report

Shintaro Haruki, Yuichiro Minami*, Katsuya Kajimoto, Bun Yashiro, Tsuyoshi Suzuki, Masatoshi Kawana and Nobuhisa Hagiwara

Department of Cardiology, Tokyo Women's Medical University, 8-1, Kawada-cho, Shinjuku-ku, Tokyo 162-8666, Japan

* Corresponding author. Tel: +81 3 3353 8111, Fax: +81 3 3356 0441, Email: yuichiro24{at}celery.ocn.ne.jp


   Abstract

It remains unclear whether the combination of dual-chamber (DDD) pacing and disopyramide can achieve prolonged left ventricular outflow tract (LVOT) gradient reduction and symptom relief in patients with obstructive hypertrophic cardiomyopathy (HCM). In an HCM patient with a severe LVOT gradient, the combination of DDD pacing and disopyramide achieved marked improvement of gradient in the catheter laboratory and also after medium-term follow-up. The patient's severe dyspnoea was alleviated during the follow-up period. This combination might enable physicians to treat and manage elderly symptomatic obstructive HCM patients with a severe LVOT gradient more effectively and less invasively.

Key Words: Hypertrophic cardiomyopathy • Dual chamber pacing • Disopyramide

Received April 9, 2009; Revised October 1, 2009; Accepted October 7, 2009


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