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European Journal of Heart Failure 2007 9(9):955-958; doi:10.1016/j.ejheart.2007.05.012
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© 2007 European Society of Cardiology

First use of cardiac contractility modulation (CCM) in a patient failing CRT therapy: Clinical and technical aspects of combined therapies

Christian Butter*, Jürgen Meyhöfer, Martin Seifert, Michael Neuss and Hans-Heinrich Minden

Heart Center Brandenburg in Bernau/Berlin, Department of Cardiology Ladeburger Str. 17, 16321 Bernau b. Berlin, Germany

* Corresponding author. Tel.: +49 3338 694610/11; fax: +49 3338 694644. E-mail address: c.butter{at}immanuel.de


  Abstract

Cardiac contractility modulating (CCM) signals delivered by the OPTIMIZER System are being investigated as a treatment for medically refractory heart failure. Previous chronic studies of CCM have excluded patients with prolonged QRS and a cardiac resynchronization therapy (CRT) device. However, symptoms persist in more than 25% of these CRT patients. CCM may offer a therapeutic option for these non-responders. Here we report the first use of CCM signals in a patient who did not respond to treatment with a CRT-D device. We show that the implantation is technically feasible, that the OPTIMIZER and CRT-D devices can coexist without interference and that acute haemodynamic and clinical improvements can be observed. The results suggest that systematic investigation of CCM treatment in CRT non-responders is warranted.

Key Words: Heart failure • Cardiac contractility modulation • Cardiac resynchronization therapy • Internal cardiac defibrillator

Received March 5, 2007; Revised April 18, 2007; Accepted May 17, 2007


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