Skip Navigation

European Journal of Heart Failure 2007 9(9):917-921; doi:10.1016/j.ejheart.2007.06.013
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (5)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Oudiz, R. J.
Right arrow Articles by Wasserman, K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Oudiz, R. J.
Right arrow Articles by Wasserman, K.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 2007 European Society of Cardiology

Effect of sildenafil on ventilatory efficiency and exercise tolerance in pulmonary hypertension{star}

Ronald J. Oudiza,c,*, Giorgio Roveranb,c, James E. Hansenb,c, Xing-Guo Sunb,c and Karlman Wassermanb,c

a Division of Cardiology USA
b Division of Respiratory and Critical Care Physiology and Medicine USA
c Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center Torrance, CA, USA

* Corresponding author. Liu Center for Pulmonary Hypertension 1124 W. Carson Street, #405 Torrance, CA 90502, USA. Tel.: +1 310 222 2515; fax: +1 310 787 0448. E-mail address: oudiz{at}humc.edu


  Abstract

Background: The pulmonary vasculopathy in pulmonary arterial hypertension (PAH) results in increased resistance to pulmonary blood flow, limiting the cardiac output required for the increased O2 demands of exercise.

Aims: We sought to determine the physiologic basis for clinical improvement in PAH patients receiving sildenafil, hypothesizing that the key mechanisms of improvement are improved blood flow and ventilatory efficiency, leading to improved exercise capacity and O2 pulse over time.

Methods: We studied 28P AH patients with (n=14) and without (n=14) sildenafil treatment. All received warfarin and diuretic therapy, and 13/14 sildenafil-treated patients were already receiving specific PAH drugs. Cardiopulmonary exercise testing was performed before and after sildenafil.

Results: Peak VO2, peak O2 pulse, VE/CO2 and PETCO2, were 0.84±0.1 L/min, 6.1±0.7 mL beat–1, 49±2 and 26±1.5 mm Hg, and improved after adding sildenafil to 0.91±0.1 L/min, 6.8±0.8 mL beat–1, 43±2, and 30±1.9, respectively, whereas control patients worsened (p=0.012, 0.008, 0.008 and 0.0002, treated vs. controls, respectively).

Conclusions: Sildenafil improves PETCO2, VE/VCO2, peak O2 pulse and peak VO2 during exercise compared to controls. A prospective, placebo-controlled study is needed to validate these findings.

Key Words: Pulmonary arterial hypertension • Cardiopulmonary exercise testing • Ventilatory efficiency • Pulmonary heart disease

Received June 27, 2007; Accepted June 27, 2007

{star} This research was supported by NIH grant # 1 K23 RR17596-01 and General Clinical Research Centers grant # MO1 RR 425.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Eur Respir JHome page
A. J. Peacock, R. Naeije, N. Galie, and L. Rubin
End-points and clinical trial design in pulmonary arterial hypertension: have we made progress?
Eur. Respir. J., July 1, 2009; 34(1): 231 - 242.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
V. V. McLaughlin, D. B. Badesch, M. Delcroix, T. R. Fleming, S. P. Gaine, N. Galie, J. S. R. Gibbs, N. H. Kim, R. J. Oudiz, A. Peacock, et al.
End Points and Clinical Trial Design in pulmonary arterial hypertension.
J. Am. Coll. Cardiol., June 30, 2009; 54(1 Suppl): S97 - 107.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
A. Giardini, A. Hager, A. E. Lammers, G. Derrick, J. Muller, G.-P. Diller, K. Dimopoulos, D. Odendaal, G. Gargiulo, F. M. Picchio, et al.
Ventilatory efficiency and aerobic capacity predict event-free survival in adults with atrial repair for complete transposition of the great arteries.
J. Am. Coll. Cardiol., April 28, 2009; 53(17): 1548 - 1555.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.