© 2007 European Society of Cardiology
Impact of heart failure and left ventricular function on long-term survival — Report of a community-based cohort study in Taiwan
a Department of Emergency Medicine, National Taiwan University Medical College and National Taiwan University Hospital, Taipei, Taiwan
b Department of Internal Medicine (Cardiology), National Taiwan University Medical College and National Taiwan University Hospital, Taipei, Taiwan
c Institute of Preventive Medicine, School of Public Health, National Taiwan University, Taipei, Taiwan
d Institute of Environmental Medicine, China Medical University, Taichung, Taiwan
e Department of Internal Medicine (Cardiology), Min-Sheng General Hospital, Taoyuan, Taiwan
* Corresponding author. Department of Internal Medicine (Cardiology), National Taiwan University Hospital, #7 Chung-Shan S. RD, Taipei, Taiwan, 100. Tel: +886 2 2395 9911; fax: +886 2 2351 9736. E-mail address: ytlee{at}ha.mc.ntu.edu.tw
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Abstract |
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Background: There is little community-based information on heart failure (HF) prognosis in ethnic Chinese populations, in whom there is a low prevalence of coronary heart disease.
Aims: To study the impact of HF and left ventricular function on long-term all-cause mortality.
Methods and results: This community-based prospective cohort study included 2660 subjects (1215 men, 1445 women, mean age 54.4±11.9 years) over a 10 year follow-up period. The prevalence of HF was 5.5%. Hypertension was the most common factor related to HF. The five and ten year all-cause mortality was higher in the HF/preserved LVEF group (14.1% and 24.4%) and the HF/impaired LVEF group (29.2% and 48.2%) than in the HF-free group (6.0% and 14.6%, p<0.0001 for both). In multivariable Cox analyses, controlling for sex, LV mass, atrial fibrillation, hypertension, coronary heart disease, HF/preserved LVEF and HF/impaired LVEF were important predictors of all-cause mortality (p=0.007).
Conclusions: Hypertension is a major heart failure related disease. HF and LV systolic dysfunction are associated with a significant increase in all-cause mortality in an ethnic Chinese population.
Key Words: Heart failure • Systolic function • All-cause mortality • Community-based • Chinese
Received April 26, 2006; Revised December 26, 2006; Accepted February 26, 2007