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European Journal of Heart Failure 2007 9(6-7):579-586; doi:10.1016/j.ejheart.2007.01.011
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© 2007 European Society of Cardiology

Alteration of myocardial sarcoplasmic reticulum Ca2+-ATPase and Na+–Ca2+ exchanger expression in human left ventricular volume overload

Przemyslaw Leszek*, Malgorzata Szperl, Anna Klisiewicz, Jadwiga Janas, Andrzej Biederman, Tomasz Rywik, Walerian Piotrowski, Mieczyslaw Kopacz and Jerzy Korewicki

Heart Failure and Transplantology Department, National Institute of Cardiology, 04-628 Warsaw, Alpejska 42 St, Poland

* Corresponding author. Tel: +48 22 34 34 483; fax: +48 22 34 34 522. E-mail address: leszekp{at}ikard.pl


  Abstract

Background: Reduced myocardial contractility is often attributed to altered Ca2+ transients and expression of Ca2+-ATPase of the SR (SERCA) and Na+/Ca2+exchanger (NCX) genes.

Aims: To assess myocardial expression of SERCA and NCX protein levels in left ventricular (LV) remodelling due to chronic severe mitral regurgitation (MR).

Methods: Myocardial expression of SERCA/NCX in biopsy specimens obtained during mitral surgery was assessed in 36 MR patients with LV remodelling and plasma neurohumoral/cytokine activation and in four non-failing hearts (NFH).

Results: Myocardial protein levels of SERCA were significantly (20%) lower in the MR group than in NFH group (p=0.016). No significant changes in NCX were observed. However, a lack of homogeneity with regard to SERCA/NCX proteins was observed. Moreover, SERCA was negatively correlated with BNP (r=–0.49, p=0.02), TNF{alpha} (r=0.68, p=0.0005) and IL-6 (r=–0.52, p=0.02), whereas NCX was only negatively correlated with TNF{alpha} (r=–0.62, p=0.002).

Conclusions: MR patients showed wide variations in SERCA/NCX protein expression. Myocardial protein levels of SERCA were significantly lower in the MR population. Moreover, a correlation between BNP, cytokines (IL-6, TNF{alpha}) and the expression of SERCA/NCX proteins was observed.

Key Words: Calcium • Proteins • Myocardium • Remodelling • Heart Failure • Chronic mitral regurgitation

Received May 16, 2006; Revised November 11, 2006; Accepted January 29, 2007

{star} The study was supported by Polish Ministry of Science Grant No 3 PO5B 10123.


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