© 2006 European Society of Cardiology
Hyperuricaemia and long-term outcome after hospital discharge in acute heart failure patients
Cardiology Department, University Hospital Virgen de la Arrixaca, University of Murcia Spain
* Corresponding author. Cardiology Department, University Hospital Virgen de la Arrixaca, Ctra. Madrid-Cartagena s/n, 30120 Murcia, Spain. Tel.: +34 968 369445; fax: +34 968 369662. E-mail address: dapascual{at}servicam.com
 |
Abstract |
|---|
Background: Uric acid (UA) may be involved in chronic heart failure (HF) pathogenesis, entailing a worse outcome. The purpose of this study was to examine the role of hyperuricaemia as a prognostic marker after hospital discharge in acute HF patients.
Methods: We studied 212 patients consecutively discharged after an episode of acute HF with LVEF<40%. Blood samples for UA measurement were extracted in the morning prior to discharge. The evaluated endpoints were death and new HF hospitalization.
Results: Mean UA levels were 7.4±2.4 mg/dl (range 1.6 to 16 mg/dl), with 127 (60%) of patients being within the range of hyperuricaemia. Hyperuricaemia was associated with a higher risk of death (n=48) (HR 2.0, 95% CI 1.1–3.9, p=0.028), new HF readmission (n=67) (HR 1.8, 95% CI 1.1–3.1, p=0.023) and the combined event (n=100) (HR 1.9, 95% CI 1.2–2.9, p=0.004). At 24 months, cumulative event-free survival was lower in the two higher UA quartiles (36.9% and 40.7% vs. 63.5% and 59.5%, log rank=0.006). After adjustment for potential confounders, hyperuricaemia remains an independent risk factor for adverse outcomes (HR 1.6, 95% CI 1.1–2.6, p=0.02).
Conclusions: In hospitalized patients with acute HF and LV systolic dysfunction, hyperuricaemia is a long-term prognostic marker for death and/or new HF readmission.
Key Words: Acute • Heart failure • Systolic function • Prognosis • Uric acid
Received March 13, 2006; Revised June 22, 2006; Accepted September 5, 2006
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  E. Krishnan Hyperuricemia and Incident Heart Failure Circ Heart Fail, November 1, 2009; 2(6): 556 - 562. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. S. Ross, G. K. Mulvey, B. Stauffer, V. Patlolla, S. M. Bernheim, P. S. Keenan, and H. M. Krumholz Statistical Models and Patient Predictors of Readmission for Heart Failure: A Systematic Review Arch Intern Med, July 14, 2008; 168(13): 1371 - 1386. [Abstract] [Full Text] [PDF]
|
|