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European Journal of Heart Failure 2007 9(5):466-468; doi:10.1016/j.ejheart.2006.10.019
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© 2006 European Society of Cardiology

Elevated serum uric acid levels impair coronary microvascular function in patients with idiopathic dilated cardiomyopathy

Hakan Gullua,*, Dogan Erdogana, Mustafa Caliskana, Derya Toka, Sevsen Kulaksizoglub, Aylin Yildirira and Haldun Muderrisoglua

a Baskent University, Faculty of Medicine, Department of Cardiology Ankara, Turkey
b Baskent University, Faculty of Medicine, Department of Clinical Biochemistry Ankara, Turkey

* Corresponding author. Baskent University, Konya Teaching and Medical Research Center, Cardiology Department, Hoca Cihan Mah, Saray Cad, No 1, Selcuklu, Konya, Turkey. Tel.: +90 332 2570606x2111; fax: +90 332 2476886.E-mail address: gulluhakan{at}hotmail.com


  Abstract

In patients with idiopathic dilated cardiomyopathy (IDC), attenuated coronary flow reserve (CFR) and elevated serum uric acid levels have been reported. In this study, we investigated whether increased uric acid levels correlate with the degree of coronary microvascular dysfunction.

Serum uric acid levels were measured in 29 patients with IDC (mean age: 57.0±10.8 years, 10 female), and each patient also underwent transthoracic echocardiographic examination including CFR measurement. The study population was divided into two groups according to the median CFR value (lower CFR group and higher CFR group). Uric acid levels were significantly higher in the lower CFR group than in the higher CFR group (7.59±2.56 vs 4.80±0.80 mg/dL, P=0.000). CFR correlated significantly and inversely to serum uric acid (r=–0.570, P=0.001). Logistic regression analysis revealed that uric acid level was the only independent predictor of CFR (B=–1080, P=0.015).

We found a possibly clinically important negative association between serum uric acid levels and CFR in patients with IDC.

Key Words: Dilated cardiomyopathy • Coronary flow reserve • Uric acid

Received May 21, 2006; Revised September 19, 2006; Accepted October 31, 2006


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