© 2007 European Society of Cardiology
Anaemia and renal function in heart failure due to idiopathic dilated cardiomyopathy
a Faculty of Health Sciences, University of Queensland Brisbane, Australia
b Soweto Cardiovascular Research Unit, Department of Cardiology, Chris Hani Baragwanath Hospital, University of the Witwatersrand Johannesburg, Republic of South Africa
c Department of Medicine, Johannesburg Hospital, University of the Witwatersrand Republic of South Africa
d Preventative Cardiology, Baker Heart Research Institute Melbourne, Australia
* Corresponding author. Soweto Cardiovascular Research Unit, Department of Cardiology, Chris Hani Baragwanath Hospital, P.O. Bertsham 2013, South Africa. Tel.: +27 11 9338197; fax: +27 11 9388945. E-mail address: sliwa-hahnlek{at}mdh-africa.org
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Abstract |
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Background: Anaemia and renal dysfunction are common in patients with heart failure (HF). Most studies involve western cohorts with ischaemic aetiology receiving treatment likely to impair renal function.
Aims: To investigate the frequency of anaemia and renal dysfunction and the relationship between the two within a cohort of 163 newly diagnosed Black African idiopathic cardiomyopathy patients prior to commencing HF treatments and compare those findings to those of western HF cohorts.
Methods: Single-centre retrospective analysis. Anaemia defined as haemoglobin concentration <13.0 g/dL for males (n=85) and <12 g/dL for females (n=78). Probable renal dysfunction defined as an estimated glomerular filtration rate of <60 mL/min/1.73 m2, using serum creatinine concentrations.
Results: The mean age was 48±11 years, 52% were male. Overall, 13.5% of patients were anaemic and 11.8% had evidence of renal dysfunction, while 1.2% had both. Renal dysfunction was significantly more common in older patients (mean age 58±13 vs. 47±10 years: p<0.001).
Conclusion: The frequency of anaemia and renal dysfunction in this cohort was lower than that reported in western HF cohorts. These data infer a more limited relationship between HF, anaemia and renal dysfunction in patients without atherothrombotic disease; hence extrapolation of HF data from the western world to other populations should be interpreted cautiously.
Key Words: Heart failure • Africa • Cardiomyopathy • Renal function • Anaemia
Received May 26, 2006; Revised September 12, 2006; Accepted October 16, 2006
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