© 2007 European Society of Cardiology
Sleep disturbances independently predict heart failure in overweight middle-aged men
a Department of Public Health and Caring Sciences, Section of Geriatrics, Uppsala University Uppsala Science Park, SE-751 85 Uppsala, Sweden
b Department of Medical Sciences, Uppsala University Uppsala, Sweden
c Astra Zeneca R&D Mölndal, Sweden
* Corresponding author. Visiting address: Dag Hammarskjölds väg 14B, Uppsala, Sweden. Tel.: +46 18 6117662; fax: +46 18 6117976. E-mail address: erik.ingelsson{at}pubcare.uu.se
 |
Abstract |
|---|
Background: Sleep disturbances are associated with manifest heart failure (HF). However, the relationship between sleep disturbances and incident HF has been less studied.
Aims: To investigate self-reported sleep disturbances as predictors of HF in a longitudinal, community-based cohort of 2314 middle-aged men.
Methods and results: Data on self-reported sleep disturbances, as well as established risk factors for HF were collected and analyzed using Cox proportional hazards analyses. In multivariable Cox proportional hazards models adjusted for established risk factors for HF, the presence at baseline of sleep disturbances (hazard ratio [HR], 1.52; 95% confidence interval [CI], 1.16–1.99; p=0.002) was an independent risk factor for HF. There was evidence of effect modification between BMI and sleep disturbances. In multivariable-adjusted models, sleep disturbance (HR, 1.58; 95% CI, 1.13–2.21; p=0.008) was an independent risk factor for HF in overweight participants (BMI>25), but not in normal-weight participants (BMI
25). All results remained similar in a sub-sample excluding all participants suffering from a myocardial infarction during follow-up.
Conclusions: Self-reported sleep disturbances imply an increased risk of subsequent HF in overweight middle-aged men, via mechanisms largely independent of established risk factors for HF, including an interim myocardial infarction.
Key Words: Heart failure • Sleep disorders • Epidemiology • Risk factors
Received February 2, 2006; Revised April 24, 2006; Accepted May 22, 2006
Lars Lind is a part time employee at Astra Zeneca R&D, Mölndal, Sweden, and part time employed at Uppsala University. Astra Zeneca has no interests in this project and has not given any financial support. Thus, there are no conflicts of interest for any of the authors.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  A. W. Roberts, A. L. Clark, and K. K. Witte Review article: Left ventricular dysfunction and heart failure in metabolic syndrome and diabetes without overt coronary artery disease -- do we need to screen our patients? Diabetes and Vascular Disease Research, July 1, 2009; 6(3): 153 - 163. [Abstract] [PDF]
|
|