Skip Navigation

European Journal of Heart Failure 2007 9(2):136-143; doi:10.1016/j.ejheart.2006.05.014
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by De Keulenaer, G. W.
Right arrow Articles by Brutsaert, D. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by De Keulenaer, G. W.
Right arrow Articles by Brutsaert, D. L.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 2007 European Society of Cardiology

Systolic and diastolic heart failure: Different phenotypes of the same disease?

Gilles W. De Keulenaer* and Dirk L. Brutsaert

Department of Physiology, University of Antwerp, Antwerp, Belgium and Division of Cardiology, Middelheim Hospital Groenenborgerlaan 171, 2020 Antwerpen, Belgium

* Corresponding author. Tel.: +32 3 2653 277; fax: +32 3 2653 276. E-mail address: gilles.dekeulenaer{at}ua.ac.be


  Abstract

Traditional pathophysiological concepts of chronic heart failure have largely focused on the haemodynamic consequences of ventricular systolic dysfunction. How these concepts relate to the pathophysiology of diastolic heart failure, i.e., heart failure with a preserved ejection fraction is, however, unclear, causing uncertainty about pathophysiology, diagnosis and management.

Recent measurements of regional myocardial systolic function in patients with diastolic heart failure indicate that systolic and diastolic heart failure may be more closely related than previously anticipated. Rather than being considered as separate diseases with a distinct pathophysiology, systolic and diastolic heart failure may be merely different clinical presentations within a phenotypic spectrum of one and the same disease. In this review, we will interpret these new insights in a broader conceptual context of chronic heart failure and design novel paradigms in which systolic and diastolic heart failure jointly progress in a pathophysiological time trajectory of only one disease.

Key Words: Chronic heart failure • Diastole • Relaxation • Ventricular function

Received October 26, 2005; Revised February 20, 2006; Accepted May 24, 2006


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Eur Heart JHome page
R. Wachter, S. Schmidt-Schweda, D. Westermann, H. Post, F. Edelmann, M. Kasner, C. Luers, P. Steendijk, G. Hasenfuss, C. Tschope, et al.
Blunted frequency-dependent upregulation of cardiac output is related to impaired relaxation in diastolic heart failure
Eur. Heart J., August 30, 2009; (2009) ehp341v1.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
G. W. De Keulenaer and D. L. Brutsaert
The Heart Failure Spectrum: Time for a Phenotype-Oriented Approach
Circulation, June 23, 2009; 119(24): 3044 - 3046.
[Full Text] [PDF]

Home page
 HeartHome page
M. Kamalesh
Diabetes and prognosis: are systolic and diastolic heart failure different?
Heart, February 1, 2009; 95(3): 178 - 179.
[Full Text] [PDF]

Home page
 Age AgeingHome page
M. Tretjak and M. Kozelj
Tissue Doppler annular velocities, NT-proBNP and exercise capacity in healthy elderly
Age Ageing, May 1, 2008; 37(3): 336 - 339.
[Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
R. W. Schrier
Decreased Effective Blood Volume in Edematous Disorders: What Does This Mean?
J. Am. Soc. Nephrol., July 1, 2007; 18(7): 2028 - 2031.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.