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European Journal of Heart Failure 2007 9(2):124-128; doi:10.1016/j.ejheart.2006.05.009
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© 2007 European Society of Cardiology

Viewpoint: The prothrombotic state in heart failure: A maladaptive inflammatory response?

Aun-Yeong Chong and Gregory Y.H. Lip*

Haemostasis, Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital Dudley Road, Birmingham B18 7QH, England, United Kingdom

* Corresponding author. Tel.: +44 121 507 5080; fax: +44 121 554 4083. E-mail address: g.y.h.lip{at}bham.ac.uk


  Abstract

Patients with heart failure (HF) are at an increased risk of stroke, sudden death and venous thromboembolism, which are all linked to thrombus formation (thrombogenesis). The present ‘viewpoint’ article will discuss how the prothrombotic state in HF may be perpetuated by a chronic inflammatory state that is maladaptive. Indeed, there is considerable evidence that thrombogenesis and endothelial (dys)function can be intimately linked to inflammation in HF.

Key Words: Prothrombotic state • Inflammation • Heart failure

Received September 28, 2005; Revised April 7, 2006; Accepted May 17, 2006


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