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European Journal of Heart Failure 2007 9(11):1081-1085; doi:10.1016/j.ejheart.2007.09.004
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© 2007 European Society of Cardiology

Tobacco smoke-induced left ventricular remodelling is not associated with metalloproteinase-2 or -9 activation

Edson Castardeli, Daniella R. Duarte, Marcos F. Minicucci, Paula S. Azevedo, Beatriz B. Matsubara, Luiz S. Matsubara, Álvaro O. Campana, Sergio A.R. Paiva and Leonardo A.M. Zornoff*

Departamento de Clinica Médica, Faculdade de Medicina de Botucatu, UNESP — São Paulo State University Botucatu, Brazil

* Corresponding author. Departamento de Clínica Médica, Faculdade de Medicina de Botucatu, Rubião Júnior s/n, Botucatu, SP, Brazil, CEP: 18618-000. Tel.: +55 14 38222969; fax: +55 14 38222238. E-mail address: lzornoff{at}fmb.unesp.br


  Abstract

Aim: To investigate the role of MMP-2 and MMP-9 in cardiac remodelling induced by tobacco smoke exposure in rats.

Methods: Rats were allocated into two groups: C (n=9): control animals; ETS (n=9): exposed to tobacco smoke. After 4months, the animals underwent echocardiography, morphometric study and determination of MMP-2 and MMP-9 activity.

Results: ETS rats had larger diastolic (C=15.6 ±1.2mm/kg, ETS=18.0±0.9mm/kg; p < 0.001) and systolic (C=7.3±1.2mm/kg, ETS=9.2±0.9mm/kg; p=0.001) ventricular diameters adjusted for body weight. Fractional shortening (C53–4.8%, ETS+48±3.3%; p=0.031) and ejection fraction (C=0.89±0.03, ETS=0.86±0.02; p=0.030) were smaller in the ETS group. Myocyte cross-sectional area (C=245±8µm2, ETS=253±8µm2; p=0.028) was higher in ETS rats. There were no differences in MMP-2 (C=50±14%; ETS=43±11%, p=0.228) or MMP-9 (C=0.36±0.3%; ETS=0.62±0.3%, p=0.630) activity between the groups.

Conclusion: MMP-2 and MMP-9 did not participate in the remodelling process induced by tobacco smoke exposure.

Key Words: Ventricular function • Cardiac remodelling • Ventricular dilatation

Received April 26, 2007; Revised June 28, 2007; Accepted September 13, 2007


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 Eur J Heart FailHome page
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Cigarette smoke-induced left ventricular remodelling is associated with activation of mitogen-activated protein kinases
Eur J Heart Fail, November 1, 2008; 10(11): 1057 - 1064.
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