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European Journal of Heart Failure 2007 9(1):2-3; doi:10.1016/j.ejheart.2006.07.006
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© 2007 European Society of Cardiology

Metabolic disturbances in chronic heart failure: A case for the "macho" approach with testosterone?!

Mitja Lainscak, Wolfram Doehner and Stefan D. Anker

Applied Cachexia Research Unit, Department of Cardiology, Campus Virchow Clinic, Charité-Universitätsmedizin Berlin, Germany General Hospital Murska Sobota, Department of Internal Medicine Murska Sobota, Slovenia
Applied Cachexia Research Unit, Department of Cardiology, Campus Virchow Clinic, Charité-Universitätsmedizin Berlin, Germany
Applied Cachexia Research Unit, Department of Cardiology, Campus Virchow Clinic, Charité-Universitätsmedizin Berlin, Germany Department of Cardiac Medicine, National Heart and Lung Institute London, UK

* Corresponding author. Applied Cachexia Research Unit, Department of Cardiology, Campus Virchow Clinic, Charité-Universitätsmedizin Berlin, Augustenburger Platz 1, D-13353 Berlin, Germany E-mail address: s.anker{at}cachexia.de


  Abstract

Chronic heart failure (CHF) primarily affects the cardiovascular system. In addition, there is strong evidence that CHF is a complex metabolic disorder. Metabolic abnormalities include insulin resistance and lack of anabolic hormone activity. To date there have been few interventional trials targeting insulin sensitivity. A recent study suggests a link between testosterone therapy and improvements in insulin sensitivity, measured using the homeostatic model assessment (HOMA-IR). We discuss this study in detail. Further studies are needed to substantiate this link and to generally explore the value of testosterone therapy in CHF patients.

Key Words: Cachexia • Testosterone • Insulin resistance

Received May 25, 2006;
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