Skip Navigation

European Journal of Heart Failure 2006 8(1):2-6; doi:10.1016/j.ejheart.2005.04.011
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (9)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Schäfer, S.
Right arrow Articles by Linz, W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Schäfer, S.
Right arrow Articles by Linz, W.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 2005 European Society of Cardiology

Impaired left ventricular relaxation in type 2 diabetic rats is related to myocardial accumulation of N{varepsilon}-(carboxymethyl) lysine

Stefan Schäfer*, Jochen Huber, Cornelia Wihler, Hartmut Rütten, Andreas E. Busch and Wolfgang Linz

Therapeutic Department Cardiovascular Diseases Aventis Pharma Deutschland GmbH, Building H 821, D-65926, Frankfurt am Main, Germany

* Corresponding author. Tel.: +49 69 30513391; fax: +49 69 30516394. E-mail address: stefan.schaefer{at}aventis.com


  Abstract

Myocardial dysfunction in the absence of myocardial ischemia is frequent in patients with diabetes mellitus but the underlying pathomechanism is unclear. We investigated whether accumulation of advanced glycation end products (AGEs) in the diabetic myocardium is related to its functional abnormalities.

In 11 male homozygous Zucker diabetic fatty rats (ZDF/Gmi-fa/fa) aged 37 weeks (OBESE) and 11 non-obese, non-diabetic littermates (LEAN), we measured left ventricular function (pressure–volume catheter) and levels of N{varepsilon}-(carboxymethyl) lysine (CML), a prototypical AGE, in serum and the left ventricle (competitive enzyme linked immuno-assay).

Overt diabetes mellitus (HbA1c >9%) was present in all OBESE animals but not in LEAN. Systolic left ventricular function was not different between the groups, but the markers of left ventricular relaxation, dP/dtmin and the relaxation constant {tau}, were impaired in OBESE. In parallel, CML levels were increased in serum (273±15 vs. 197±10 ng/ml, p<0.05) and in the left ventricle (18.4±1.1 vs. 12.5±2.0 ng/mg protein, p<0.05) in OBESE compared to LEAN. There was a linear correlation between {tau} and the left ventricular CML levels (r=0.65; p<0.05).

We conclude that type 2 diabetes is associated with predominant left ventricular diastolic dysfunction. Myocardial accumulation of advanced glycation end products may contribute to relaxation abnormalities in type 2 diabetes.

Key Words: Zucker diabetic fatty rat • Diabetic cardiomyopathy • Advanced glycation end products

Received February 2, 2005; Accepted April 27, 2005


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
T. Radovits, S. Korkmaz, S. Loganathan, E. Barnucz, T. Bomicke, R. Arif, M. Karck, and G. Szabo
Comparative investigation of the left ventricular pressure-volume relationship in rat models of type 1 and type 2 diabetes mellitus
Am J Physiol Heart Circ Physiol, July 1, 2009; 297(1): H125 - H133.
[Abstract] [Full Text] [PDF]

Home page
 Eur J Heart FailHome page
J. W.L. Hartog, A. A. Voors, S. J.L. Bakker, A. J. Smit, and D. J. van Veldhuisen
Advanced glycation end-products (AGEs) and heart failure: Pathophysiology and clinical implications
Eur J Heart Fail, December 1, 2007; 9(12): 1146 - 1155.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
S. A. Marsh, P. C. Powell, A. Agarwal, L. J. Dell'Italia, and J. C. Chatham
Cardiovascular dysfunction in Zucker obese and Zucker diabetic fatty rats: role of hydronephrosis
Am J Physiol Heart Circ Physiol, July 1, 2007; 293(1): H292 - H298.
[Abstract] [Full Text] [PDF]

Home page
 Eur J Heart FailHome page
R. Wachter, C. Luers, S. Kleta, K. Griebel, C. Herrmann-Lingen, L. Binder, N. Janicke, D. Wetzel, M. M. Kochen, and B. Pieske
Impact of diabetes on left ventricular diastolic function in patients with arterial hypertension
Eur J Heart Fail, May 1, 2007; 9(5): 469 - 476.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.