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European Journal of Heart Failure 2005 7(7):1180-1182; doi:10.1016/j.ejheart.2005.02.001
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© 2005 European Society of Cardiology

Attenuation of postoperative noradrenaline need by nitric oxide inhibition using L-NMMA

Anders Franco-Cerecedaa,*, Peter Holma, Fredrik Bredinb and Christoffer Addinga

a Department of Cardiothoracic Surgery, Karolinska University Hospital S-171 76 Stockholm, Sweden
b Department of Cardiothoracic Anaesthesia, Karolinska University Hospital 171 76 Stockholm, Sweden

* Corresponding author. Tel.: +46 8 517 708 26; fax: +46 8 32 27 01. E-mail address: andfra{at}mbox.ki.se


  Abstract

In the present report we describe that NG-monomethyl-L-arginine acetate, a non-specific nitric oxide synthesis inhibitor, administered at 1 mg kg–1 h–1 to a patient with critical hypotension following mitral valve surgery combined with passive containment surgery, increased the urinary output and arterial blood pressure while the need for noradrenaline was rapidly attenuated. Again increasing the noradrenaline infusion in the presence of NG-monomethyl-L-arginine acetate caused a dramatic increase of the blood pressure.

Key Words: Congestive heart failure • L-NMMA • Mitral valve surgery • Nitric oxide • Passive containment surgery

Received November 1, 2004; Accepted February 8, 2005


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