© 2005 European Society of Cardiology
Clinical trials update from the European Society of Cardiology meeting 2005: CARE-HF extension study, ESSENTIAL, CIBIS-III, S-ICD, ISSUE-2, STRIDE-2, SOFA, IMAGINE, PREAMI, SIRIUS-II and ACTIVE
a Department of Cardiology, University of Hull, Castle Hill Hospital Cottingham, Kingston-upon-Hull, HU15 5JQ, UK
b Department of Cardiology, Hull Royal Infirmary Anlaby Road, Kingston-upon-Hull, HU3 2JZ, UK
c Division of Cardiology, Mount Sinai Hospital, University Health Network 600 University Avenue, Toronto, ON, Canada M5J 1X5
* Corresponding author. Tel.: +44 1482 624086; fax: +44 1482 624085. E-mail address: a.p.coletta{at}hull.ac.uk
 |
Abstract |
|---|
This article provides information and a commentary on trials presented at the European Society of Cardiology meeting held in September 2005, relevant to the pathophysiology, prevention and treatment of heart failure. All reports should be considered as preliminary data, as analyses may change in the final publication. In the CARE-HF extension study, the benefits of cardiac resynchronisation therapy (CRT) observed in the original study were maintained over an increased follow-up period. A study of oral enoximone (25–50 mg t.i.d.) in advanced heart failure (ESSENTIAL) showed limited benefit compared to placebo. The CIBIS-III study showed that heart failure therapy could be safely initiated with bisoprolol followed by the addition of enalapril. A subcutaneous ICD system (S-ICD) showed potential as an alternative to a transvenous ICD. In the ISSUE-2 study, an implantable loop recorder was used to guide therapy in patients with recurrent syncope. The selective endothelin antagonist sitaxsentan improved 6-MWT and functional class in patients with pulmonary arterial hypertension in the STRIDE-2 study. In SOFA, fish oil had no beneficial effect on the incidence of life-threatening arrhythmias in patients with an ICD. In IMAGINE, quinapril showed no benefit when administered to patients following CABG. Perindopril reduced cardiac remodelling in post-MI patients with normal LV function in PREAMI. SIRIUS-II showed encouraging results for the use of intravenous ularitide in symptomatic decompensated chronic heart failure. The ACTIVE W study of warfarin versus aspirin plus clopidogrel in atrial fibrillation has been stopped due to superiority of warfarin.
Key Words: CARE-HF extension study • ESSENTIAL • CIBIS-III • S-ICD • ISSUE-2 • STRIDE-2 • SOFA • IMAGINE • PREAMI • SIRIUS-II • ACTIVE
Received September 15, 2005; Revised September 20, 2005; Accepted September 20, 2005
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  A. Kulik, M. A. Brookhart, R. Levin, M. Ruel, D. H. Solomon, and N. K. Choudhry Impact of Statin Use on Outcomes After Coronary Artery Bypass Graft Surgery Circulation, October 28, 2008; 118(18): 1785 - 1792. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. J.A. Jenkins MD PhD, A. R. Josse MSc, J. Beyene PhD, P. Dorian MD MSc, M. L. Burr MD DSc (Me, R. LaBelle BSc, C. W.C. Kendall PhD, and S. C. Cunnane PhD Fish-oil supplementation in patients with implantable cardioverter defibrillators: a meta-analysis Can. Med. Assoc. J., January 15, 2008; 178(2): 157 - 164. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Feneck Phosphodiesterase inhibitors and the cardiovascular system CEACCP, December 1, 2007; 7(6): 203 - 207. [Full Text] [PDF]
|
|
|
|
 |
|
 M. Metra, P. Ponikowski, K. Dickstein, J. J.V. McMurray, A. Gavazzi, C.-H. Bergh, A. G. Fraser, T. Jaarsma, A. Pitsis, P. Mohacsi, et al. Advanced chronic heart failure: A position statement from the Study Group on Advanced Heart Failure of the Heart Failure Association of the European Society of Cardiology Eur J Heart Fail, June 1, 2007; 9(6-7): 684 - 694. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Goyal, J. H. Alexander, G. E. Hafley, S. H. Graham, R. H. Mehta, M. J. Mack, R. K. Wolf, L. H. Cohn, N. T. Kouchoukos, R. A. Harrington, et al. Outcomes Associated With the Use of Secondary Prevention Medications After Coronary Artery Bypass Graft Surgery Ann. Thorac. Surg., March 1, 2007; 83(3): 993 - 1001. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. M. deGoma, R. H. Vagelos, M. B. Fowler, and E. A. Ashley Emerging Therapies for the Management of Decompensated Heart Failure: From Bench to Bedside J. Am. Coll. Cardiol., December 19, 2006; 48(12): 2397 - 2409. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Piccirillo, D. Magri, S. di Carlo, T. De Laurentis, A. Torrini, S. Matera, M. Magnanti, L. Bernardi, F. Barilla, R. Quaglione, et al. Influence of cardiac-resynchronization therapy on heart rate and blood pressure variability: 1-year follow-up Eur J Heart Fail, November 1, 2006; 8(7): 716 - 722. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Leineweber, M. Bohm, and G. Heusch Cyclic Adenosine Monophosphate in Acute Myocardial Infarction With Heart Failure: Slayer or Savior? Circulation, August 1, 2006; 114(5): 365 - 367. [Full Text] [PDF]
|
|
|
|
 |
|
 B. Houweling, D. Merkus, O. Sorop, F. Boomsma, and D. J. Duncker Role of endothelin receptor activation in secondary pulmonary hypertension in awake swine after myocardial infarction J. Physiol., July 15, 2006; 574(2): 615 - 626. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. A. Lane, C. J. Boos, and G. Y. H. Lip Anticoagulation Control With Vitamin K Antagonists: How Well Are We Doing? Chest, May 1, 2006; 129(5): 1122 - 1124. [Full Text] [PDF]
|
|
|
|
 |
|
 N.P. Jenkins, N.C. Davidson, and D.H. Bennett Successful treatment of drug refractory ventricular tachycardia by omega-3 fatty acid supplementation Europace, May 1, 2006; 8(5): 330 - 332. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J G Coghlan and C Handler Connective tissue associated pulmonary arterial hypertension Lupus, March 1, 2006; 15(3): 138 - 142. [Abstract] [PDF]
|
|
|
|
|
|
R. Willenheimer, H. Krum, D. J. van Veldhuisen, C. Funck-Brentano, E. Erdmann, W. R. Meyer, and for the CIBIS III Steering Committee and Investiga Comment on "Clinical trials update from the European Society of Cardiology meeting 2005: CIBIS-III, by JGF Cleland and others" Eur J Heart Fail, March 1, 2006; 8(2): 219 - 220. [Full Text] [PDF]
|
|
|
|
|
|
K. Dickstein Clinical trials update from the European Society of Cardiology Meeting 2005: CIBIS-III. Response to correspondence from R. Willenheimer et al. Eur J Heart Fail, March 1, 2006; 8(2): 221 - 222. [Full Text] [PDF]
|
|
|
|
 |
|
 J. G.F. Cleland, K. Goode, O. Khaleva, and N. Khan How many patients need cardiac resynchronization therapy? Eur. Heart J., February 1, 2006; 27(3): 251 - 252. [Full Text] [PDF]
|
|
|
|
|
|
J. G.F. Cleland, N. Freemantle, A. P. Coletta, and A. L. Clark Clinical trials update from the American Heart Association: REPAIR-AMI, ASTAMI, JELIS, MEGA, REVIVE-II, SURVIVE, and PROACTIVE Eur J Heart Fail, January 1, 2006; 8(1): 105 - 110. [Abstract] [Full Text] [PDF]
|
|