Skip Navigation

European Journal of Heart Failure 2005 7(4):525-531; doi:10.1016/j.ejheart.2004.12.010
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Lukowicz, T.v.
Right arrow Articles by Luchner, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lukowicz, T.v.
Right arrow Articles by Luchner, A.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 2005 European Society of Cardiology

BNP as a marker of diastolic dysfunction in the general population: Importance of left ventricular hypertrophy

T.v. Lukowicza, M. Fischera, H.W. Henseb, A. Döringc, J. Stritzked, G. Rieggera, H. Schunkertd and A. Luchnera,1,*

a Klinik und Poliklinik für Innere Medizin II, Klinikum der Universität Regensburg 93042 Regensburg, Germany
b Institut für Epidemiologie und Sozialmedizin, Universität Münster Germany
c GSF, Institut für Epidemiologie Neuherberg, Germany
d Medizinische Klinik II, Universitätsklinikum Schleswig-Holstein Campus Lübeck, Germany

* Corresponding author. Tel.: +49 941 944 7211; Fax: +49 941 944 7213. E-mail address: andreas.luchner{at}klinik.uni-regensburg.de


  Abstract

BNP is a marker of systolic left ventricular dysfunction (LVSD) and heart failure. To assess BNP for the detection of diastolic dysfunction in the general population, we examined 1678 subjects within an age- and sex-stratified survey (MONICA Augsburg). BNP was measured using a commercially available RIA (Shionogi).

BNP increased in subjects with diastolic dysfunction (mean 20.3±4.7 pg/ml vs. control 9.6±0.5 pg/ml, p<0.001), but to a lesser extent than in subjects with LV hypertrophy (LVH, mean 37.3±49.1 pg/ml, p<0.001 vs. control) or LVSD (mean 76.2±23.2 pg/ml, p<0.001 vs. control). Individuals with sole diastolic abnormality displayed BNP concentrations at the control level (mean 9.7±1.7 pg/ml). In univariate analysis, age, BMI, systolic blood pressure, left atrial size, LV mass index, diastolic dysfunction and EF displayed a significant correlation with BNP (p<0.001). However, LV mass index displaced diastolic dysfunction as a significant predictor of BNP in multivariate analysis. Upon ROC analysis, sensitivity and specificity for the detection of diastolic dysfunction by BNP were only 61% and 55%, respectively. Nevertheless, a normal BNP test virtually excluded the presence of diastolic dysfunction and concomitant LVH (NPV 99.9%).

Increased BNP concentrations in subjects with diastolic dysfunction are strongly related to LVH. Population-wide screening for diastolic dysfunction with BNP cannot be recommended although a normal BNP test usually excludes diastolic dysfunction and LV hypertrophy.

Key Words: Heart failure • Diastolic dysfunction • BNP • LV hypertrophy • Echocardiography

Received July 13, 2004; Revised November 30, 2004; Accepted December 20, 2004

1 For the MONICA investigators. The MONICA Augsburg study was initiated by U. Keil and co-workers.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Eur. J. Cardiothorac. Surg.Home page
A. A. Alsaddique
Recognition of diastolic heart failure in the postoperative heart
Eur. J. Cardiothorac. Surg., December 1, 2008; 34(6): 1141 - 1148.
[Abstract] [Full Text] [PDF]

Home page
 CJASNHome page
R. Tagore, L. H. Ling, H. Yang, H.-Y. Daw, Y.-H. Chan, and S. K. Sethi
Natriuretic Peptides in Chronic Kidney Disease
Clin. J. Am. Soc. Nephrol., November 1, 2008; 3(6): 1644 - 1651.
[Abstract] [Full Text] [PDF]

Home page
 JAMAHome page
R. F. Machado, A. Anthi, M. H. Steinberg, D. Bonds, V. Sachdev, G. J. Kato, A. M. Taveira-DaSilva, S. K. Ballas, W. Blackwelder, X. Xu, et al.
N-terminal pro-brain natriuretic peptide levels and risk of death in sickle cell disease.
JAMA, July 19, 2006; 296(3): 310 - 318.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.