© 2005 European Society of Cardiology
Enhanced oxidative stress in coronary heart disease and chronic heart failure as indicated by an increased 8-epi-PGF2
a Department of Angiology, Medical University of Vienna Vienna, Austria
b Department of Nuclear Medicine, Medical University of Vienna Vienna, Austria
c Institute of Nuclear Medicine, University of Perugia Perugia, Italy
d Wilhelm Auerswald Atherosclerosis Research Group (ASF) Vienna, Austria
* Corresponding author. Wilhelm Auerswald Atherosclerosis Research Group (ASF), Nadlergasse 1, Vienna A-1090, Austria. Tel.: +43-1-4082633; fax: +43-1-4081366. E-mail address: helmut.sinzinger{at}univie.ac.at
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Abstract |
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The role of oxidation injury as an important factor in the pathophysiology of cardiomyopathy (CMP) has recently gained increasing interest. Semiquantitative analysis for isoprostane, 8-epi-prostaglandin F2
(8-epi-PGF2), and oxidised low-density lipoprotein (ox-LDL) of coronary vascular tissue samples derived from CMP patients revealed an increased extent and intensity of uptake as compared to the respective controls. To evaluate oxidative stress in vivo, we examined plasma, serum, salivary, and urinary 8-epi-PGF2 in patients with dilated CMP (n=20) and ischemic CMP (n=20) with decreased left ventricular ejection fraction (LVEF). Patients with coronary heart disease (CHD) (n=20) and 20 healthy, age-matched, and sex-matched controls were investigated in parallel. 8-Epi-PGF2 levels were correlated with the functional severity of heart failure [New York Heart Association (NYHA) classification] and LVEF. 8-Epi-PGF2 levels were matched according to risk factors (smoking and hypercholesterolemia) and were significantly higher in patients with CMP as compared to healthy controls and patients with CHD in all investigated compartments. A positive correlation between NYHA stages and 8-epi-PGF2, as well as a negative correlation to LVEF, could be demonstrated in a subgroup analysis.
These findings reflect the enhanced oxidation injury in patients with CMP and, to a lesser extent, in CHD as compared to healthy controls, thus highly indicating the relevance of oxidative stress for the pathogenesis and progression of cardiovascular disease.
Key Words: CCSC, Canadian Cardiovascular Society Classification • CHD, coronary heart disease • CMP, cardiomyopathy • HDL, high-density lipoprotein • LDL, low-density lipoprotein • LVEF, left ventricular ejection fraction • NYHA, New York Heart Association • 8-Epi-PGF2 8-epi-prostaglandin F2
Received January 16, 2004; Revised March 25, 2004; Accepted May 5, 2004
1 Dr. Anthony Oguogho was on sabbatical leave from the Department of Physiology, Edo State University of Basic Sciences, Ekpoma, Nigeria, and was supported by a stipendium of the ÖAAD (Austrian Academic Exchange Division).
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