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European Journal of Heart Failure 2004 6(4):399-402; doi:10.1016/j.ejheart.2003.12.006
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© 2004 European Society of Cardiology

Cardiac chimerism in recipients of peripheral-blood and bone marrow stem cells

Antoni Bayes-Genisa,*, Eduardo Muñiz-Diazb, Lluis Catasusc, Marina Arillab, Carmen Rodriguezc, Jordi Sierrad, Pedro J. Madozb and Juan Cincaa

a Cardiology Service, Hospital de la Santa Creu i Sant Pau C/Sant Antoni Ma Claret 167, 08025 Barcelona, Spain
b Blood Bank, Hospital de la Santa Creu i Sant Pau C/Sant Antoni Ma Claret 167, 08025 Barcelona, Spain
c Pathology Service, Hospital de la Santa Creu i Sant Pau C/Sant Antoni Ma Claret 167, 08025 Barcelona, Spain
d Hematology Service, Hospital de la Santa Creu i Sant Pau C/Sant Antoni Ma Claret 167, 08025 Barcelona, Spain

* Corresponding author. Tel: +93-556-92-58; fax: +93-291-94-24. E-mail address: abayesgenis{at}hsp.santpau.es


  Abstract

Multipotent progenitor cells have the ability to differentiate into most somatic cell types, including cardiac myocytes. We sought to investigate cardiac chimerism after peripheral-blood and bone marrow stem cell transplantation. Between 10 and 17 highly polymorphic short tandem repeat (STR) markers were assayed in DNA obtained from donors’ peripheral blood, recipients’ peripheral blood before transplantation, and the recipient's heart in every patient. Gender and non-gender STR donor alleles were identified in the recipient heart in three patients. Using a highly sensitive PCR assay to determine donor and recipient genotypes, we confirmed the existence of cardiac chimerism in recipients of peripheral-blood and bone marrow stem cells.

Received July 11, 2003; Revised October 27, 2003; Accepted December 22, 2003


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