© 2004 European Society of Cardiology
Natriuretic peptides for risk stratification of patients with acute coronary syndromes
The Cardiovascular Research Unit of the Fondazione Sacco and the Department of Cardiology Ospedale G.B. Morgagni, Forlì, Italy
* Corresponding author. Present address. Fondazione Cardiologica Sacco, Piazza F.lli Ruffini, 6, 47100, Forlì, Italy. Tel.: +39-543-33283; Fax: +39-543-31720 E-mail address: galvanim{at}tin.it
 |
Abstract |
|---|
Natriuretic peptides (BNP and NT-proBNP) have been shown to be useful tools for risk stratification of patients with acute myocardial ischemia encompassing the whole spectrum of acute coronary syndromes (ACS), particularly for prediction of mortality. Both BNP and NT-proBNP possess several characteristics of the ideal biomarker, showing independent and incremental prognostic value above traditional clinical, electrocardiographic, and biochemical (particularly troponin) risk indicators. Specifically, in ACS patients, BNP and NT-proBNP have powerful prognostic value both in patients without a history of previous heart failure or without clinical or instrumental signs of left ventricular dysfunction on admission or during hospital stay. They can also be easily and rapidly measured in an emergency context. We have performed a meta-analysis of available studies concerning the prognostic value of natriuretic peptides. Our results show that the prognostic value of natriuretic peptides is similar: (1) both at short- and long-term; (2) when natriuretic peptides are measured at first patient contact or during hospital stay; (3) for BNP or NT-proBNP; and (4) in patients with ST elevation myocardial infarction or no ST elevation ACS. These data suggest that natriuretic peptide measurement should be integrated into routine evaluation of patients with an ACS.
Key Words: Natriuretic peptide • Acute myocardial infarction • Prognosis
Received December 29, 2003; Accepted January 14, 2004
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  A. Hammerer-Lercher, B. Halfinger, B. Sarg, J. Mair, B. Puschendorf, A. Griesmacher, N. A. Guzman, and H. H. Lindner Analysis of Circulating Forms of proBNP and NT-proBNP in Patients with Severe Heart Failure Clin. Chem., May 1, 2008; 54(5): 858 - 865. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M G Nicholls, C M Frampton, and T G Yandle BNP: not just for heart failure Heart, January 1, 2008; 94(1): 6 - 7. [Full Text] [PDF]
|
|
|
|
 |
|
 C. J. Boos, S. K. Soor, D. Kang, and G. Y.H. Lip Relationship between circulating endothelial cells and the predicted risk of cardiovascular events in acute coronary syndromes Eur. Heart J., May 1, 2007; 28(9): 1092 - 1101. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Ben-Dor, M. Haim, E. Rechavia, D. Murninkas, D. Harell, A. Porter, Z. Iakobishvili, A. Battler, and D. Hasdai Serum NT-proBNP Concentrations in the Early Phase Do Not Predict the Severity of Systolic or Diastolic Left Ventricular Dysfunction Among Patients With ST-Elevation Acute Myocardial Infarction Angiology, January 1, 2007; 57(6): 686 - 693. [Abstract] [PDF]
|
|
|
|
|
|
G A Whalley, G D Gamble, and R N Doughty Restrictive diastolic filling predicts death after acute myocardial infarction: systematic review and meta-analysis of prospective studies Heart, November 1, 2006; 92(11): 1588 - 1594. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Verges, M. Zeller, J. Desgres, G. Dentan, Y. Laurent, L. Janin-Manificat, I. L'Huillier, G. Rioufol, J.-C. Beer, H. Makki, et al. High plasma N-terminal pro-brain natriuretic peptide level found in diabetic patients after myocardial infarction is associated with an increased risk of in-hospital mortality and cardiogenic shock Eur. Heart J., September 1, 2005; 26(17): 1734 - 1741. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Prontera, S. Storti, M. Emdin, C. Passino, L. Zyw, G. C. Zucchelli, and A. Clerico Comparison of a Fully Automated Immunoassay with a Point-of-Care Testing Method for B-Type Natriuretic Peptide Clin. Chem., July 1, 2005; 51(7): 1274 - 1276. [Full Text] [PDF]
|
|
|
|
|
|
A. I. Larsen and K. Dickstein BNP in acute coronary syndromes: the heart expresses its suffering Eur. Heart J., August 1, 2004; 25(15): 1284 - 1286. [Full Text] [PDF]
|
|