Skip Navigation

European Journal of Heart Failure 2004 6(1):47-54; doi:10.1016/S1388-9842(03)00038-2
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Anderson, R.A.
Right arrow Articles by Frenneaux, M.P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Anderson, R.A.
Right arrow Articles by Frenneaux, M.P.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 2004 European Society of Cardiology

Determinants of platelet responsiveness to nitric oxide in patients with chronic heart failure

R.A. Andersona,*, G.R. Ellisb, Y.Y. Chirkovc, A.S. Holmesc, N. Paynea, D.J. Blackmana, S.K. Jacksona, M.J. Lewisa, J.D. Horowitzc and M.P. Frenneauxa

a Wales Heart Research Institute University of Wales College of Medicine, Cardiff, Wales, UK
b Department of Cardiology Royal Glamorgan Hospital, Llantrisant, Rhondda Cynon Taf, Wales, UK
c Department of Cardiology Queen Elizabeth Hospital, University of Adelaide, Adelaide, Australia

* Corresponding author. Wales Heart Research Institute, Health Park, Cardiff, Wales, UK CF14 4XN. Tel.: +44-02920-618625; fax.: +44-02920-743739. E-mail address: raanderson{at}ukgateway.net


  Abstract

Congestive heart failure (CHF) is associated with oxidative stress. Platelet responsiveness to nitric oxide (NO) donors, are impaired in patients with angina pectoris, possibly by increasing oxidative stress. We investigated the occurrence of platelet resistance to NO in patients, with ischaemic or non-ischaemic cardiomyopathy compared with normal subjects. Anti-aggregatory effects of sodium nitroprusside (SNP), oxidative stress and whole blood superoxide anion content were determined, with correlates of responsiveness to SNP. Inhibition of platelet aggregation by SNP was 65.4±3.55% in controls and 59.3±4.1% in CHF (P=ns) despite increased oxidative stress and post-aggregation O2– in CHF patients. However, subsets of CHF patients have NO-resistant platelets: this is associated with increasing age and/or increased oxidative stress (both p<0.05).

Key Words: Heart failure • Platelets • Free radicals

Received June 19, 2002; Revised November 11, 2002; Accepted January 23, 2003


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
A. Schafer, D. Fraccarollo, M. Eigenthaler, P. Tas, A. Firnschild, S. Frantz, G. Ertl, and J. Bauersachs
Rosuvastatin Reduces Platelet Activation in Heart Failure: Role of NO Bioavailability
Arterioscler Thromb Vasc Biol, May 1, 2005; 25(5): 1071 - 1077.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.